Reactome | TEAD1 [nucleoplasm]

TEAD1 [nucleoplasm]

Stable Identifier

R-HSA-2032774

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional enhancer factor TEF-1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) transcription (Homo sapiens)
        
        CD274 Transcription (Homo sapiens)
        
        YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Homo sapiens)
        
        TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Homo sapiens)
        
        TEAD1 [nucleoplasm] (Homo sapiens)
        
        YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm] (Homo sapiens)
        
        TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
        
        TEADs [nucleoplasm] (Homo sapiens)
        
        TEAD1 [nucleoplasm] (Homo sapiens)
        
        YAP1/TAZ binding to CD274 gene (Homo sapiens)
        
        TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
        
        TEADs [nucleoplasm] (Homo sapiens)
        
        TEAD1 [nucleoplasm] (Homo sapiens)
        
        YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm] (Homo sapiens)
        
        TEAD:WWTR1(TAZ) [nucleoplasm] (Homo sapiens)
        
        TEADs [nucleoplasm] (Homo sapiens)
        
        TEAD1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28347 TEAD1

Gene Names

TEAD1, TCF13, TEF1

Chain

chain:1-426

Reference Genes

BioGPS Gene:7003 TEAD1

COSMIC (genes):TEAD1 TEAD1

CTD Gene:7003 TEAD1

dbSNP Gene:7003 TEAD1

ENSEMBL:ENSG00000187079 TEAD1

HGNC:11714 TEAD1

KEGG:hsa:7003 TEAD1

Monarch:7003 TEAD1

NCBI Gene:7003 TEAD1

OMIM:189967 TEAD1

UCSC:P28347 TEAD1

Reference Transcript

RefSeq:NM_021961.6 TEAD1

Participates

as a component of

as a member of

as an input of

YAP1 binds TEAD1 (Homo sapiens)

Inferred To

egl-44 [nucleoplasm] (Caenorhabditis elegans)

Tead1 [nucleoplasm] (Mus musculus)

tead1a [nucleoplasm] (Danio rerio)

sd [nucleoplasm] (Drosophila melanogaster)

TEC1 [nucleoplasm] (Saccharomyces cerevisiae)

TEAD1 [nucleoplasm] (Bos taurus)

TEAD1 [nucleoplasm] (Canis familiaris)

TEAD1 [nucleoplasm] (Gallus gallus)

TEAD1 [nucleoplasm] (Rattus norvegicus)

TEAD1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_068780.2

Guide to Pharmacology - Targets

3240

OpenTargets

ENSG00000187079

ENSEMBL

ENSP00000435233, ENSP00000334754, ENST00000527636, ENST00000334310, ENSG00000187079

HPA

ENSG00000187079-TEAD1

GeneCards

TEAD1

PRO

P28347

Pharos - Targets

P28347

Orphanet

TEAD1

GlyGen

P28347

PDB

4Z8E, 4RE1, 9FZA, 5NNX, 9GAX, 2HZD, 3KYS, 7CMM, 6HIL, 8Q68, 7ZJP, 6IM5

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.94	11
UniProt:P03070 LT			0.623	3
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.564	2
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.527	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.527	3
UniProt:Q15562 TEAD2	1	TEAD2 [nucleoplasm] (R-HSA-2032763)	0.527	3
UniProt:Q26366 VG			0.524	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.483	2
UniProt:Q14135 VGLL4			0.483	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.462	2
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.462	2

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