Reactome | TBX5 [nucleoplasm]

TBX5 [nucleoplasm]

Stable Identifier

R-HSA-2032786

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

T-box transcription factor TBX5

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99593 TBX5

Gene Names

TBX5

Chain

chain:1-518

Reference Genes

BioGPS Gene:6910 TBX5

COSMIC (genes):TBX5 TBX5

CTD Gene:6910 TBX5

dbSNP Gene:6910 TBX5

ENSEMBL:ENSG00000089225 TBX5

HGNC:11604 TBX5

KEGG:hsa:6910 TBX5

Monarch:6910 TBX5

NCBI Gene:6910 TBX5

OMIM:601620 TBX5

UCSC:Q99593 TBX5

Reference Transcript

Participates

as an output of

Expression of TBX5 in cardiogenesis (Homo sapiens)

as an input of

as a component of

Inferred To

tbx5a [nucleoplasm] (Danio rerio)

Homologues of TBX5 [nucleoplasm] (Caenorhabditis elegans)

tbx-35 [nucleoplasm] (Caenorhabditis elegans)

Tbx5 [nucleoplasm] (Mus musculus)

Tbx5 [nucleoplasm] (Rattus norvegicus)

tbx5 [nucleoplasm] (Xenopus tropicalis)

tbx-7 [nucleoplasm] (Caenorhabditis elegans)

TBX5 [nucleoplasm] (Bos taurus)

TBX5 [nucleoplasm] (Canis familiaris)

TBX5 [nucleoplasm] (Gallus gallus)

TBX5 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENSG00000089225, ENST00000405440, ENSP00000309913, ENSP00000384152, ENST00000526441, ENST00000310346, ENSP00000337723, ENST00000349716, ENSP00000433292

OpenTargets

ENSG00000089225

GeneCards

TBX5

HPA

ENSG00000089225-TBX5

PRO

Q99593

Pharos - Targets

Q99593

Orphanet

TBX5

PDB

2X6U, 2X6V, 5BQD, 4S0H

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.558	4
UniProt:Q9UQB8-6 BAIAP2			0.556	3
UniProt:O75800 ZMY10			0.556	3
IntAct:EBI-1212037 TBE			0.525	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.462	3

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