palmitoylation of eNOS

Stable Identifier
R-HSA-203567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DHHC-21 is a Golgi-localized acyl transferase that palmitoylates eNOS, which targets eNOS to plasmalemmal caveolae. Localization to this microdomain is likely to optimize eNOS activation and the extracellular release of nitric oxide.

Literature References
PubMed ID Title Journal Year
8692835 Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

Garcia-Cardena, G, Oh, P, Liu, J, Schnitzer, JE, Sessa, WC

Proc Natl Acad Sci U S A 1996
16864653 Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase

Fernandez-Hernando, C, Fukata, M, Bernatchez, PN, Fukata, Y, Lin, MI, Bredt, DS, Sessa, WC

J Cell Biol 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
palmitoyltransferase activity of ZDHHC21 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created