Reactome | DUSP1 [nucleoplasm]

DUSP1 [nucleoplasm]

Stable Identifier

R-HSA-203796

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dual specificity protein phosphatase 1, DUS1_HUMAN

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External Reference Information

External Reference

UniProt:P28562 DUSP1

Gene Names

DUSP1, CL100, MKP1, PTPN10, VH1

Chain

chain:1-367

Reference Genes

BioGPS Gene:1843 DUSP1

COSMIC (genes):DUSP1 DUSP1

CTD Gene:1843 DUSP1

dbSNP Gene:1843 DUSP1

ENSEMBL:ENSG00000120129 DUSP1

ENSEMBL_homo_sapiens_GENE:ENSG00000120129.6 DUSP1

HGNC:3064 DUSP1

KEGG Gene (Homo sapiens):1843 DUSP1

Monarch:1843 DUSP1

NCBI Gene:1843 DUSP1

OMIM:600714 DUSP1

UCSC:P28562 DUSP1

Reference Transcript

RefSeq:NM_004417.3 DUSP1

Other Identifiers

1005_at

11715765_a_at

11715766_a_at

11752993_a_at

11758730_x_at

17002846

1843

201041_PM_s_at

201041_s_at

201044_PM_x_at

201044_x_at

2887310

2887311

2887312

2887314

2887315

2887316

2887318

2887320

2887321

8115831

A_23_P110712

GE61271

GO:0000278

GO:0001706

GO:0002376

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005737

GO:0006470

GO:0007049

GO:0007059

GO:0007155

GO:0007162

GO:0008138

GO:0008285

GO:0008330

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0022414

GO:0023052

GO:0033550

GO:0035335

GO:0035970

GO:0036211

GO:0043226

GO:0043407

GO:0043409

GO:0048856

GO:0048870

GO:0051019

GO:0051447

GO:0070262

GO:0090027

GO:0090266

GO:0140014

GO:0140096

GO:1903753

GO:1990869

HMNXSV003055852

Hs.171695.0.A1_3p_a_at

ILMN_1781285

PH_hs_0010276

TC05002066.hg

X68277_at

g7108342_3p_a_at

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Homo sapiens)

Inferred To

ENSRNOG00000069024 [nucleoplasm] (Rattus norvegicus)

mpl2 [nucleoplasm] (Dictyostelium discoideum)

Dusp1 [nucleoplasm] (Mus musculus)

Dusp1 [nucleoplasm] (Rattus norvegicus)

mpl1 [nucleoplasm] (Dictyostelium discoideum)

DUSP1 [nucleoplasm] (Bos taurus)

DUSP1 [nucleoplasm] (Canis familiaris)

DUSP1 [nucleoplasm] (Dictyostelium discoideum)

DUSP1 [nucleoplasm] (Gallus gallus)

DUSP1 [nucleoplasm] (Plasmodium falciparum)

DUSP1 [nucleoplasm] (Sus scrofa)

dusp1 [nucleoplasm] (Danio rerio)

dusp1 [nucleoplasm] (Xenopus tropicalis)

Homologues of DUSP1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of DUSP1 [nucleoplasm] (Rattus norvegicus)

mpl3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_004408.1

OpenTargets

ENSG00000120129

ZINC - Substances

DUS1_HUMAN

GeneCards

P28562

HPA

ENSG00000120129-DUSP1

ZINC target

P28562

Ensembl

ENST00000239223, ENSG00000120129, ENSP00000239223

PRO

P28562

Pharos - Targets

P28562

HMDB Protein

HMDBP08908

PDB

6D66, 6D67, 6APX, 6D65

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.767	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.706	3
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.576	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.544	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.544	3

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