ERKs are inactivated by dual-specific phosphatases (DUSPs)

Stable Identifier
R-HSA-203797
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ERKs are inactivated by dual-specific phosphatases (DUSPs)
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Over 10 dual specificity phosphatases (DUSPs) active on MAP kinases are known. Among them, some possess good ERK docking sites and so are more specific for the ERKS (DUSP 3, 4, 6, 7), others are more specific for p38MAPK (DUSP1 and 10), while others do not seem to discriminate. It is noteworthy that transcription of DUSP genes is induced by growth factor signaling itself, so that these phosphatases provide feedback attenuation of signaling. Moreover, differential activation of DUSPs by different stimuli is thought to contribute to pathway specificity.
Literature References
PubMed ID Title Journal Year
17322878 A module of negative feedback regulators defines growth factor signaling

Siwak, D, Jacob-Hirsch, J, Lu, Y, Amit, I, Tarcic, G, Segal, E, Zhang, F, Shay, T, Vaisman, N, Yarden, Y, Domany, E, Amariglio, N, Mills, GB, Alon, U, Rechavi, G, Katz, M, Lahad, J, Citri, A

Nat Genet 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of ERK-specific DUSP [nucleoplasm]

Physical Entity
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
This event is regulated
Negatively by
Regulator
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
Orthologous Events
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-11-16)
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