Reactome | DICER1 [cytosol]

DICER1 [cytosol]

Stable Identifier

R-HSA-203820

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q8N1E6 FBXL14

Expand all

External Reference Information

External Reference

UniProt:Q9UPY3 DICER1

Gene Names

DICER1, DICER, HERNA, KIAA0928

Chain

chain:1-1922

Reference Genes

BioGPS Gene:23405 DICER1

COSMIC (genes):DICER1 DICER1

CTD Gene:23405 DICER1

dbSNP Gene:23405 DICER1

ENSEMBL:ENSG00000100697 DICER1

HGNC:17098 DICER1

KEGG:hsa:23405 DICER1

Monarch:23405 DICER1

NCBI Gene:23405 DICER1

OMIM:606241 DICER1

UCSC:Q9UPY3 DICER1

Reference Transcript

Participates

as an output of

MITF-M dependent DICER1 gene expression (Homo sapiens)

as a component of

Inferred To

Dcr-1 [cytosol] (Drosophila melanogaster)

dicer1 [cytosol] (Xenopus tropicalis)

DICER1 [cytosol] (Bos taurus)

DICER1 [cytosol] (Canis familiaris)

DICER1 [cytosol] (Gallus gallus)

DICER1 [cytosol] (Sus scrofa)

Dicer1 [cytosol] (Mus musculus)

Dicer1 [cytosol] (Rattus norvegicus)

dcr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001382607.1, XP_016876610.1, NP_001278557.1, NP_001382613.1, NP_001382612.1, XP_016876609.1, NP_001382606.1, NP_001382611.1, NP_001258211.1, NP_001382608.1, NP_001382609.1, NP_001182502.1, XP_011534903.1, XP_011534902.1, XP_011534901.1, NP_803187.1, XP_011534904.1, NP_085124.2

OpenTargets

ENSG00000100697

ENSEMBL

ENST00000674628, ENSP00000502730, ENST00000531162, ENSG00000100697, ENSP00000433926, ENST00000541352, ENSP00000376783, ENSP00000437256, ENSP00000433060, ENST00000526495, ENSP00000444719, ENST00000343455, ENST00000527414, ENSP00000435681, ENST00000393063, ENSP00000343745, ENST00000529720

IntEnz

3.1.26.3

GeneCards

DICER1

HPA

ENSG00000100697-DICER1

PRO

Q9UPY3

Pharos - Targets

Q9UPY3

GlyGen

Q9UPY3

Orphanet

DICER1

PDB

4NGF, 4NHA, 4NH3, 4NH6, 5ZAM, 4NH5, 5ZAL, 2EB1, 7XW3, 4NGC, 4NGD, 7XW2, 4NGG, 5ZAK, 4NGB, 4WYQ

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15633 TARBP2	2	p-TARBP2 [cytosol] (R-HSA-9835348) TARBP2 [cytosol] (R-HSA-203864)	0.956	25
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.946	21
UniProt:Q9UL18 AGO1	2	EIF2C1 [cytosol] (R-HSA-210616) EIF2C1 [nucleoplasm] (R-HSA-5578686)	0.832	9
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.8	9
UniProt:P55265-5 ADAR			0.653	8
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.643	4
UniProt:P0C205 REX			0.61	7
UniProt:Q96DB2 HDAC11	1	HDAC11 [nucleoplasm] (R-HSA-351590)	0.597	4
UniProt:P55265-1 ADAR			0.591	4
IntAct:EBI-11169865 PRE			0.544	3
IntAct:EBI-11169820 PRE			0.544	3
IntAct:EBI-11169630 PRE-HSA-MIR-200A			0.544	2
IntAct:EBI-2938324 PRE-LET-7A-1			0.544	3
IntAct:EBI-11169796 PRE-HSA-MIR-34C			0.544	3
UniProt:O43508 TNFSF12	2	TNFSF12 [plasma membrane] (R-HSA-5667154) sTNFSF12 [extracellular region] (R-HSA-5675974)	0.543	3
UniProt:Q8IZ69 TRM2A			0.527	2
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.527	2
UniProt:O60506 HNRPQ			0.527	2
UniProt:Q3SYB3 FX4L6			0.527	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:Q8N5L8 RP25L			0.527	2
UniProt:Q08211 DHX9	3	DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168) DHX9 [nucleoplasm] (R-HSA-53517)	0.527	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	2
UniProt:Q8N4T0 CBPA6			0.527	3
UniProt:O75173 ADAMTS4	4	ADAMTS4 [extracellular region] (R-HSA-2533998) ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173253) glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5172994) O-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173144)	0.527	2
UniProt:P62701 RPS4X	2	RPS4X [cytosol] (R-HSA-72375) RPS4X [nucleoplasm] (R-HSA-6798713)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q8CJG0 Ago2	3	Ago2 [nucleoplasm] (R-MMU-5578701) Ago2 [cytosol] (R-MMU-9621518) Ago2 [cytosol] (R-MMU-209723)	0.524	2
UniProt:Q9Y6A4 CFA20			0.508	2
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.504	3
UniProt:Q96C10 DHX58	1	DHX58 [cytosol] (R-HSA-913540)	0.499	2
UniProt:Q96J94 PIWIL1	1	4xMeR-PIWIL1 [cytosol] (R-HSA-5601891)	0.499	2
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.499	2
UniProt:Q9IK90 MATRX			0.499	3
UniProt:Q12906 ILF3	3	ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [nucleoplasm] (R-HSA-9760401)	0.483	2

Cite Us!