Reactome | Microprocessor complex cleaves pri-miRNA to pre-miRNA

Microprocessor complex cleaves pri-miRNA to pre-miRNA

Stable Identifier

R-HSA-203893

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Microprocessor complex cleaves pri-miRNA to pre-miRNA

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Nuclear processing by Drosha Microprocessor complex. The primary-microRNA (pri-miRNA) is recognized by the Microprocessor complex (Drosha:DGCR8) and both strands of the pri-miRNA are cleaved by Drosha near the free 5' and 3' ends of the pri-miRNA, that is, at the ends distal from the internal loop. The product is a double-stranded RNA having 2 nucleotides protruding at the 3' end and having an internal loop.

Literature References

PubMed ID	Title	Journal	Year
25326327	Global identification of target recognition and cleavage by the Microprocessor in human ES cells Seong, Y, Lim, DH, Kim, A, Seo, JH, Lee, YS, Song, H, Kwon, YS	Nucleic Acids Res.	2014
15531877	The Microprocessor complex mediates the genesis of microRNAs Gregory, RI, Yan, KP, Amuthan, G, Doratotaj, B, Cooch, N, Shiekhattar, R, Chendrimada, TP	Nature	2004
15574589	The Drosha-DGCR8 complex in primary microRNA processing Han, J, Lee, Y, Yeom, KH, Kim, YK, Jin, H, Kim, VN	Genes Dev	2004
14508493	The nuclear RNase III Drosha initiates microRNA processing Lee, Y, Ahn, C, Han, J, Choi, H, Kim, J, Yim, J, Lee, J, Provost, P, Radmark, O, Kim, S, Kim, VN	Nature	2003