Reactome | Pol II mediated transcription of microRNA genes

Pol II mediated transcription of microRNA genes

Stable Identifier

R-HSA-203901

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Pol II mediated transcription of microRNA genes

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Transcription of miRNA genes. Most miRNAs are transcribed by RNA polymerase II. The miRNAs may be autonomous transcription units or they may be located in other transcripts, including locations within introns and other untranslated regions. Of the polymerase II transcribed miRNAs, about 60% are located in introns of protein coding genes, 12 % are in introns of non-coding RNAs, 18% are in exons of non-coding RNAs, and 10% uncertain.
A second class of miRNA genes are associated with Alu and other repetitive elements and are cotranscribed with these elements by RNA polymerase III. There are currently only a few proven examples of polymerase III transcribed miRNAs.

Literature References

PubMed ID	Title	Journal	Year
15525708	Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs Hagedorn, CH, Cai, X, Cullen, BR	RNA	2004
17099701	RNA polymerase III transcribes human microRNAs Lanier, W, Davidson, BL, Borchert, GM	Nat Struct Mol Biol	2006
15372072	MicroRNA genes are transcribed by RNA polymerase II Baek, SH, Kim, VN, Yeom, KH, Han, J, Lee, Y, Lee, S, Kim, M	EMBO J	2004
17057362	Intronic microRNA (miRNA) Lin, SL, Miller, JD, Ying, SY	J Biomed Biotechnol	2006
15364901	Identification of mammalian microRNA host genes and transcription units Bradley, A, Griffiths-Jones, S, Ashurst, JL, Rodriguez, A	Genome Res	2004