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SEC24A [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-203992
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Protein transport protein Sec24A, S24A_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Budding of COPII coated vesicle (Homo sapiens)
COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Coat Assembly (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)
COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Formation of COPII vesicle (Homo sapiens)
COPII [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Fusion of COPII vesicle with Golgi complex (Homo sapiens)
COPII [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95486 SEC24A
Gene Names
SEC24A
Chain
chain:1-1093
Reference Genes
BioGPS Gene:10802 SEC24A
COSMIC (genes):SEC24A SEC24A
CTD Gene:10802 SEC24A
dbSNP Gene:10802 SEC24A
ENSEMBL:ENSG00000113615 SEC24A
ENSEMBL_homo_sapiens_GENE:ENSG00000113615.13 SEC24A
HGNC:10703 SEC24A
KEGG Gene (Homo sapiens):10802 SEC24A
Monarch:10802 SEC24A
NCBI Gene:10802 SEC24A
OMIM:607183 SEC24A
UCSC:O95486 SEC24A
Reference Transcript
RefSeq:NM_021982.2 SEC24A
RefSeq:NM_001252231.1 SEC24A
Other Identifiers
10802
11743926_a_at
11743927_at
11757836_s_at
11759728_at
16989293
212900_PM_at
212900_at
212902_PM_at
212902_at
244841_PM_at
244841_at
2829417
2829418
2829419
2829420
2829421
2829423
2829424
2829425
2829426
2829427
2829428
2829429
2829431
2829432
2829434
2829435
2829436
2829437
2829438
2829440
2829441
2829442
2829443
2829445
2829446
2829448
2829449
2829450
2829453
2829455
2829457
2829460
2829461
2829462
34199_at
78591_at
8108099
A_14_P108339
A_23_P329593
A_23_P394605
A_33_P3331080
A_33_P3331085
GE507710
GE61763
GO:0000149
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006886
GO:0006888
GO:0008270
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0030127
GO:0031410
GO:0032374
GO:0042632
GO:0043226
GO:0046872
GO:0050714
GO:0061024
GO:0070971
GO:0090110
HMNXSV003044643
HMNXSV003047719
Hs.134218.0.A1_3p_at
Hs.211612.0.S1_3p_at
Hs.211612.0.S2_3p_at
ILMN_2126832
PH_hs_0012278
PH_hs_0041056
TC05000665.hg
Participates
as a member of
SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
p-SEC24A [cytosol]
SEC24A [ER to Golgi transport vesicle membrane]
SEC24A [cytosol]
Inferred To
SEC24A [endoplasmic reticulum membrane]
(Bos taurus)
SEC24A [endoplasmic reticulum membrane]
(Canis familiaris)
SEC24A [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SEC24A [endoplasmic reticulum membrane]
(Gallus gallus)
SEC24A [endoplasmic reticulum membrane]
(Mus musculus)
SEC24A [endoplasmic reticulum membrane]
(Plasmodium falciparum)
SEC24A [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
SEC24A [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SEC24A [endoplasmic reticulum membrane]
(Sus scrofa)
sec-24.2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Sec24AB [endoplasmic reticulum membrane]
(Drosophila melanogaster)
sec24a [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Sec24a [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001239160.1
,
NP_068817.1
OpenTargets
ENSG00000113615
GeneCards
O95486
HPA
ENSG00000113615-SEC24A
Ensembl
ENSP00000321749
,
ENST00000398844
,
ENSG00000113615
,
ENSP00000381823
,
ENST00000322887
PRO
O95486
Pharos - Targets
O95486
PDB
3EGX
,
5VNE
,
5VNM
,
5VNI
,
2NUP
,
5VNF
,
3EGD
,
5VNN
,
5VNJ
,
2NUT
,
5VNO
,
5VNG
,
5VNK
,
5VNH
,
5VNL
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