Reactome | SEC13 [ER to Golgi transport vesicle membrane]

SEC13 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-204012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

SEC13-related protein, SC13_HUMAN, SEC13L1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13 [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55735 SEC13

Gene Names

SEC13, D3S1231E, SEC13A, SEC13L1, SEC13R

Chain

initiator methionine:, chain:2-322

Reference Genes

BioGPS Gene:6396 SEC13

COSMIC (genes):SEC13 SEC13

CTD Gene:6396 SEC13

dbSNP Gene:6396 SEC13

ENSEMBL:ENSG00000157020 SEC13

HGNC:10697 SEC13

KEGG:hsa:6396 SEC13

Monarch:6396 SEC13

NCBI Gene:6396 SEC13

OMIM:600152 SEC13

UCSC:P55735 SEC13

Reference Transcript

Participates

as a component of

Other forms of this molecule

SEC13 [cytosol]

SEC13 [endoplasmic reticulum membrane]

SEC13 [lysosomal membrane]

Inferred To

SEC13 [ER to Golgi transport vesicle membrane] (Bos taurus)

SEC13 [ER to Golgi transport vesicle membrane] (Canis familiaris)

SEC13 [ER to Golgi transport vesicle membrane] (Gallus gallus)

SEC13 [ER to Golgi transport vesicle membrane] (Plasmodium falciparum)

SEC13 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

SEC13 [ER to Golgi transport vesicle membrane] (Sus scrofa)

Sec13 [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

Sec13 [ER to Golgi transport vesicle membrane] (Mus musculus)

Sec13 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

sec13 [ER to Golgi transport vesicle membrane] (Danio rerio)

sec13 [ER to Golgi transport vesicle membrane] (Dictyostelium discoideum)

sec13 [ER to Golgi transport vesicle membrane] (Schizosaccharomyces pombe)

sec13 [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

npp-20 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_109598.2, NP_899195.1, NP_001129704.1, XP_005265436.1, NP_001129498.1, XP_016862508.1

OpenTargets

ENSG00000157020

ENSEMBL

ENSP00000373312, ENSG00000157020, ENST00000383801, ENSP00000380298, ENSP00000312122, ENST00000337354, ENSP00000336566, ENST00000397109, ENST00000350697

GeneCards

SEC13

HPA

ENSG00000157020-SEC13

PRO

P55735

Pharos - Targets

P55735

GlyGen

P55735

PDB

3BG0, 3BG1, 7UHY, 7R5K, 5A9Q, 7PEQ, 7R5J

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NFH4 NUP37	2	NUP37 [nuclear envelope] (R-HSA-157745) NUP37 [cytosol] (R-HSA-376237)	0.798	8
UniProt:Q9NXC5 MIOS	1	MIOS [lysosomal membrane] (R-HSA-9638223)	0.788	8
UniProt:Q96EE3 SEH1L	1	SEH1L [lysosomal membrane] (R-HSA-9638217)	0.775	8
UniProt:Q9BW27 NUP85	2	NUP85 [nuclear envelope] (R-HSA-157741) NUP85 [cytosol] (R-HSA-376238)	0.744	7
UniProt:O94979 SEC31A	5	SEC31A [cytosol] (R-HSA-203983) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475)	0.734	7
UniProt:Q6PJI9 WDR59	1	WDR59 [lysosomal membrane] (R-HSA-9638236)	0.725	7
UniProt:P57740 NUP107	2	NUP107 [nuclear envelope] (R-HSA-157717) NUP107 [cytosol] (R-HSA-376241)	0.725	7
UniProt:Q96S15 WDR24	1	WDR24 [lysosomal membrane] (R-HSA-9638247)	0.725	7
UniProt:P49687 NU145			0.698	15
UniProt:Q96JE7-2 SEC16B			0.666	6
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.643	3
UniProt:Q8WUM0 NUP133	2	NUP133 [nuclear envelope] (R-HSA-157743) NUP133 [cytosol] (R-HSA-376251)	0.643	6
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.643	5
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.643	5
UniProt:Q12769 NUP160	2	NUP160 [nuclear envelope] (R-HSA-157721) NUP160 [cytosol] (R-HSA-376253)	0.643	6
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.636	3
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.635	3
UniProt:Q8BH74	2	Nup107 [nuclear envelope] (R-MMU-157717) Nup107 [cytosol] (R-MMU-376241)	0.564	2
UniProt:Q6PFD9	9	phospho-Nup98 [cytosol] (R-MMU-2990915) phospho-Nup98 [cytosol] (R-MMU-2990893) phospho-Nup98 [nucleoplasm] (R-MMU-2990884) phospho-Nup98 [nucleoplasm] (R-MMU-2990914) phospho-Nup98 [nuclear envelope] (R-MMU-2990895) phospho-Nup98 [nuclear envelope] (R-MMU-2990916) Nup98 [nuclear envelope] (R-MMU-2990912) Nup98 [nuclear envelope] (R-MMU-157723) Nup98 [cytosol] (R-MMU-376247)	0.564	2
UniProt:O00463 TRAF5			0.556	3
UniProt:Q96JE7 SEC16B	1	SEC16B [cytosol] (R-HSA-5685731)	0.547	3
UniProt:Q92734 TFG	7	TFG [cytosol] (R-HSA-5688159) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019)	0.527	2
UniProt:Q96BP3 PPWD1	1	PPWD1 [nucleoplasm] (R-HSA-8867893)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:Q03154 ACY1	6	ACY1 [cytosol] (R-HSA-5433075) ACY1 R353C [cytosol] (R-HSA-5579111) ACY1 P369Hfs*47 [cytosol] (R-HSA-5579105) ACY1 R197W [cytosol] (R-HSA-5579041) ACY1 E233D [cytosol] (R-HSA-5579040) ACY1 R393H [cytosol] (R-HSA-5579106)	0.527	5
UniProt:P52948 NUP98			0.527	5
UniProt:Q96EA4 SPDL1	1	SPDL1 [cytosol] (R-HSA-377733)	0.527	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.527	3
UniProt:P09497 CLTB	5	CLTB [cytosol] (R-HSA-8856819) CLTB [trans-Golgi network membrane] (R-HSA-5333645) CLTB [clathrin-coated endocytic vesicle membrane] (R-HSA-5138428) CLTB [lysosomal membrane] (R-HSA-2980616) CLTB [plasma membrane] (R-HSA-2980617)	0.527	2
UniProt:P11274 BCR	4	BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) BCR [cytosol] (R-HSA-195200)	0.527	4
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.527	4
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.488	2