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CyP60 chaperones Basigin

Stable Identifier
R-HSA-204500
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway.

Literature References
PubMed ID Title Journal Year
15946952 Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60 J Biol Chem 2005
Participants
Participant Of
Orthologous Events