BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

Stable Identifier
R-HSA-2045911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).)

Literature References
PubMed ID Title Journal Year
9235916 p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Chantry, D, Vojtek, A, Kashishian, A, Holtzman, DA, Wood, C, Gray, PW, Cooper, JA, Hoekstra, MF

J Biol Chem 1997
18025150 Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase

Aiba, Y, Kameyama, M, Yamazaki, T, Tedder, TF, Kurosaki, T

Blood 2008
1372019 Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes

Gold, MR, Chan, VW, Turck, CW, DeFranco, AL

J Immunol 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol 3-kinase activity of BCAP Signalosome [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created