Elongation of arachidonyl-CoA to docosatetraenoyl-CoA

Stable Identifier
R-HSA-2046083
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
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Arachidonyl-CoA undergoes a two-carbon chain elongation on the carboxyl end to form docosatetraenoyl-CoA (DTA-CoA/Adrenic acid/7,10,13,16-docosatetraenoic acid (7,10,13,16-22:4(n-6)). This reaction is catalyzed by the enzymes ELOVL5 or ELOVL2. Malanoyl-CoA provides the additional two carbons required for elongation. Docosatetraenoyl-CoA is further metabolized by cyclooxygenases (COX), lipoxygenases (LO) and cytochrome P450s (CYP450s) to dihomo (DH) eicosanoids (Kopf et al. 2010, Leonard et al. 2004).

Literature References
PubMed ID Title Journal Year
10970790 Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Leonard, AE, Bobik, EG, Dorado, J, Kroeger, PE, Chuang, LT, Thurmond, JM, Parker-Barnes, JM, Das, T, Huang, YS, Mukerji, P

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created