Activation of alpha-linolenic acid to alpha-linolenoyl-CoA

Stable Identifier
R-HSA-2046085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the first step the precursor apha-linolenic (9,12,15-18:3(n-3)) acid is activated to a high energy form known as alpha-linolenoyl-CoA (9Z,12Z,15Z-octadecatrienoyl-CoA) by the iron enzyme long-chain-fatty-acid-CoA-ligase (acyl-CoA synthetase 1, ACSL1) and coenzyme A.

Literature References
PubMed ID Title Journal Year
7061494 Discovery of an arachidonoyl coenzyme A synthetase in human platelets

Wilson, DB, Prescott, SM, Majerus, PW

J Biol Chem 1982
  Nutrient Metabolism

Biosketch, M

  2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain fatty acid-CoA ligase activity of ACSL1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created