Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Stable Identifier
R-HSA-2046088
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).

Literature References
PubMed ID Title Journal Year
12716664 Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids

James, MJ, Ursin, VM, Cleland, LG

Am J Clin Nutr 2003
10899997 Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids

Parker-Barnes, JM, Das, T, Bobik, E, Leonard, AE, Thurmond, JM, Chaung, LT, Huang, YS, Mukerji, P

Proc Natl Acad Sci U S A 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created