Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA

Stable Identifier
R-HSA-2046094
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated to dihomo-gamma-linolenoyl-CoA (DGL-CoA; 8,11,14-20:3(n-6)) by the action of C18-PUFA-specific elongase 5 (ELOVL5). Two carbon atoms are added during this reaction. DGL-CoA later undergoes desaturation to form arachidonic acid (AA, 5,8,11,14-20:4(n-6)).
Depending on the cell type, DGL-CoA can also be metabolized by cyclooxygenases and lipoxygenases to produce anti-inflammatory eicosanoids (prostaglandins of series 1 (PGE1) and 15-hydroxyeico- satrienoic acid (15-HETrE)). GLA and these two oxidative metabolites exert clinical effects in a variety of diseases, including suppression of chronic inflammation, vasodilation and lowering of blood pressure, inhibition of platelet aggregation and thrombosis. (Fan et al. 2001, Fan & Chapkin 1998, Kapoor & Huang. 2006)

Literature References
PubMed ID Title Journal Year
8609415 Metabolism of gammalinolenic acid in human neutrophils

Chilton-Lopez, T, Surette, ME, Swan, DD, Fonteh, AN, Johnson, MM, Chilton, FH

J Immunol 1996
9732298 Importance of dietary gamma-linolenic acid in human health and nutrition

Fan, YY, Chapkin, RS

J Nutr 1998
10970790 Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Leonard, AE, Bobik, EG, Dorado, J, Kroeger, PE, Chuang, LT, Thurmond, JM, Parker-Barnes, JM, Das, T, Huang, YS, Mukerji, P

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created