Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
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The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).
Literature References
PubMed ID Title Journal Year
12562861 Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element

Nakamura, MT, Cho, HP, Tang, C, Clarke, SD

J Lipid Res 2003
12713571 Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity

Prouty, SM, Gordon, JS, Ge, L, Hsuan, C, Stenn, K

J Invest Dermatol 2003
11988075 The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

Jan, S, d'Andréa, S, Catheline, D, Bouriel, M, Thibault, JN, Legrand, P, Rioux, V, Guillou, H

Biochem J 2002
Catalyst Activity

linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]

Orthologous Events
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