Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

Stable Identifier
R-HSA-2046096
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).

Literature References
PubMed ID Title Journal Year
12713571 Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity

Ge, L, Gordon, JS, Hsuan, C, Stenn, K, Prouty, SM

J Invest Dermatol 2003
12562861 Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element

Tang, C, Cho, HP, Nakamura, MT, Clarke, SD

J Lipid Res 2003
11988075 The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

d'Andréa, S, Guillou, H, Jan, S, Catheline, D, Thibault, JN, Bouriel, M, Rioux, V, Legrand, P

Biochem J 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
Cite Us!