Activation of linoleic acid to linoleoyl-CoA

Stable Identifier
R-HSA-2046098
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The dietary essential fatty acid (EFA) linoleic acid (LA) is activated to a high energy form known as linoleoyl-CoA by the action of long-chain acyl-CoA synthetases (ACSLs). Thioesterification of long-chain fatty acids into their acyl-CoA derivatives is considered to be the first committed step in fatty acid metabolism. Formation of acyl-CoA allows an otherwise non-reactive fatty acid to participate in biosynthetic or catabolic pathways. This acyl CoA form is converted to its longer-chain polyunsaturated products by a series of desaturation and elongation reactions (Ellis et al. 2010, Watkins 2008).

Literature References
PubMed ID Title Journal Year
7061494 Discovery of an arachidonoyl coenzyme A synthetase in human platelets

Wilson, DB, Prescott, SM, Majerus, PW

J Biol Chem 1982
  Nutrient Metabolism

Biosketch, M

  2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain fatty acid-CoA ligase activity of ACSL1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created