Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA

Stable Identifier
R-HSA-2046100
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Eicosapentaenoyl-CoA (EPA-CoA) is transformed to docosapentaenoyl-CoA (DPA-CoA/clupanodonic acid; 7,10,13,16,19-22:5(n-3)) by addition of two carbon atoms from malanoyl-CoA. This reaction is catalyzed by the enzymes ELOVL5/2 (Leonard et al. 2004). DPA is quite high in seal oil and may act as an anti-atherogenic factor. DPA has 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. DPA may act as a precursor for production of the DPA-related D-series of resolvins or neuroprotectins (Kaur et al. 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created