Linoleic acid (LA) metabolism

Stable Identifier
R-HSA-2046105
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Pathway
Species
Homo sapiens
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Linoleic acid (LA, 18:2(n-6)) is an omega-6 fatty acid obtained through diet, mainly from vegetable oils. Omega-6 fatty acids helps stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The linoleic acid pathway involves the following steps: 18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6). Two desaturation enzymes are involved in this process: delta-6 desaturase which converts 18:2(n-6) to 18:3 (n-6) and 24:4(n-6) to 24:5(n-6) respectively, and delta-5 desaturase which converts 20:3(n-6) to 20:4(n-6). (Sprecher 2002).

Literature References
PubMed ID Title Journal Year
17168669 Gamma linolenic acid: an antiinflammatory omega-6 fatty acid

Kapoor, R, Huang, YS

Curr Pharm Biotechnol 2006
8609415 Metabolism of gammalinolenic acid in human neutrophils

Chilton-Lopez, T, Surette, ME, Swan, DD, Fonteh, AN, Johnson, MM, Chilton, FH

J Immunol 1996
10903473 Metabolism of highly unsaturated n-3 and n-6 fatty acids

Sprecher, H

Biochim Biophys Acta 2000
14636670 Elongation of long-chain fatty acids

Leonard, AE, Pereira, SL, Sprecher, H, Huang, YS

Prog Lipid Res 2004
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