B4GALTs transfer Gal to the keratan chain

Stable Identifier
R-HSA-2046265
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The family of beta 4-galactosyltransferases (B4GALTs) is composed by at least six known members with different Km and acceptor specificities (Guo et al. 2001) and probably originated by duplication (Lo et al. 1998). They mediate the transfer of galactose to N-glycan structures, either to begin, or in this case, to elongate keratan chains. B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (MIM:607091) (Hansske et al. 2002), and is expressed as two splicing isoforms of which only one is localized in the Golgi system (Lopez et al. 1991, Schaub et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1-6 homodimers [Golgi membrane]
Physical Entity
Activity
Orthologous Events