The keratan chain can be capped by N-acetylneuraminic acid

Stable Identifier
R-HSA-2046285
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human genes ST3GAL1-4 and 6 encode for sialyltransferase1-4 and 6 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa and Paulson, 1993, Basu et al. 1993, Okajima et al. 1999). They add a sialyl residue to the growing keratan chain, blocking any further chain elongation.

Literature References
PubMed ID Title Journal Year
8611500 Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line

Basu, SS, Basu, M, Li, Z, Basu, S

Biochemistry 1996
8920913 Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)

Kim, YJ, Kim, KS, Kim, SH, Kim, CH, Ko, JH, Choe, IS, Tsuji, S, Lee, YC

Biochem Biophys Res Commun 1996
10206952 Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids

Okajima, T, Fukumoto, S, Miyazaki, H, Ishida, H, Kiso, M, Furukawa, K, Furukawa, K, Urano, T

J Biol Chem 1999
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
10504389 Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver

Shang, J, Qiu, R, Wang, J, Liu, J, Zhou, R, Ding, H, Yang, S, Zhang, S, Jin, C

Eur J Biochem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-4,6 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created