Interaction of Tie2 and Grb7

Stable Identifier
R-HSA-204773
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Grb7 was initially identified as an EGF receptor binding protein and thereafter many binding partners have been reported. Grb7 interacts with Tie2/Tek in a phosphotyrosine-dependent manner through its SH2 domain.

Literature References
PubMed ID Title Journal Year
11607834 The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions

Han, DC, Shen, TL, Guan, JL

Oncogene 2001
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

Jones, N, Master, Z, Jones, J, Bouchard, D, Gunji, Y, Sasaki, H, Daly, R, Alitalo, K, Dumont, DJ

J Biol Chem 1999
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed