Interaction of Tie2 and p85 of PI3K

Stable Identifier
R-HSA-204798
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase) associates with Tie2, most likely at phosphotyrosine 1102. This association leads on to the activation of Akt/PKB, a process linked to cell survival and antiapoptosis, and that may in part account for Tie2's role in vascular growth and maintenance.

Literature References
PubMed ID Title Journal Year
9632797 Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

Kontos, CD, Stauffer, TP, Yang, WP, York, JD, Huang, L, Blanar, MA, Meyer, T, Peters, KG

Mol Cell Biol 1998
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

Jones, N, Master, Z, Jones, J, Bouchard, D, Gunji, Y, Sasaki, H, Daly, R, Alitalo, K, Dumont, DJ

J Biol Chem 1999
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