Interaction of Tie2 and Grb14

Stable Identifier
R-HSA-204813
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Grb14 is also one of the signaling partners of Tie2. The SH2 domain of Grb2 mediates binding to Tie2. It binds residues Y816, Y1108 and Y1113 respectively, in the C-terminal tail region of Tie2/Tek.

Literature References
PubMed ID Title Journal Year
11607834 The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions

Han, DC, Shen, TL, Guan, JL

Oncogene 2001
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

Jones, N, Master, Z, Jones, J, Bouchard, D, Gunji, Y, Sasaki, H, Daly, R, Alitalo, K, Dumont, DJ

J Biol Chem 1999
Participants
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