Reactome | GRB7 [cytosol]

GRB7 [cytosol]

Stable Identifier

R-HSA-204819

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Growth factor receptor-bound protein 7, Grb7 adapter protein

Locations in the PathwayBrowser for interactor UniProt:P10721 KIT

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External Reference Information

External Reference

UniProt:Q14451 GRB7

Gene Names

GRB7

Chain

chain:1-532

Reference Genes

COSMIC (genes):GRB7 GRB7

dbSNP Gene:2886 GRB7

ENSEMBL:ENSG00000141738 GRB7

Participates

as a member of

as a component of

as an input of

Inferred To

Grb7 [cytosol] (Mus musculus)

Grb7 [cytosol] (Rattus norvegicus)

grb7 [cytosol] (Xenopus tropicalis)

GRB7 [cytosol] (Bos taurus)

GRB7 [cytosol] (Canis familiaris)

GRB7 [cytosol] (Sus scrofa)

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.779	5
UniProt:P21860 ERBB3			0.688	7
UniProt:Q8IWV1 LAX1			0.666	4
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417_D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.59	4
UniProt:Q92730 RND1	1	RND1 [plasma membrane] (R-HSA-396949)	0.581	4
UniProt:Q8TAK6 OLIG1			0.57	3
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.57	3
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.558	2
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	3
UniProt:Q9NQ86 TRIM36	1	TRIM36 [cytosol] (R-HSA-976029)	0.556	3
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.525	2
ChEBI:16500 PI5P			0.525	4
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.525	2
ChEBI:17283 PI3P			0.525	2
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [ChEBI:16152]	3	PI(3,4)P2 [early endosome membrane] (R-ALL-1806238) PI(3,4)P2 [Golgi membrane] (R-ALL-1806230) PI(3,4)P2 [plasma membrane] (R-ALL-202247)	0.525	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.525	2
UniProt:Q5SQ64 LY6G6F	2	LY6G6F [plasma membrane] (R-HSA-8862974) LY6G6F [platelet alpha granule membrane] (R-HSA-8862968)	0.524	2
UniProt:O00165 HAX1			0.508	2
UniProt:P54762 EPHB1	6	p-Y594,Y600-EPHB1 [plasma membrane] (R-HSA-3928347) EPHB1 [plasma membrane] (R-HSA-2682340) EPHB1 (18-?) [extracellular region] (R-HSA-3928393) EPHB1 (?-984) [plasma membrane] (R-HSA-3928402) EPHB1 (?-984) [cytosol] (R-HSA-3928438) EPHB1 (?-?) [plasma membrane] (R-HSA-3928449)	0.508	4
UniProt:P62161 CALM			0.499	9
UniProt:O43257 ZNHI1			0.488	2
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.462	4