Interaction of Tie2 and Ang4

Stable Identifier
R-HSA-204824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Ang4 represents a third protein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and induces phosphorylation in Tie2.

Literature References
PubMed ID Title Journal Year
11969368 The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development

Ward, NL, Dumont, DJ

Semin Cell Dev Biol 2002
10051567 Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

Valenzuela, DM, Griffiths, JA, Rojas, J, Aldrich, TH, Jones, PF, Zhou, H, McClain, J, Copeland, NG, Gilbert, DJ, Jenkins, NA, Huang, T, Papadopoulos, N, Maisonpierre, PC, Davis, S, Yancopoulos, GD

Proc Natl Acad Sci U S A 1999
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