Reactome: A Curated Pathway Database

Interaction of Tie2 and Dok-2

Stable Identifier
R-HSA-204850
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Dok-2 is a member of a docking proteins class, termed the DOK family. The DOK family members are characterized by an N-terminal pleckstrin homology (PH) domain followed by a central PTB domain and a proline- and tyrosine-rich C-terminal tail. Dok-2 is recruited to activated Tie2 via its PTB domain, which results in its subsequent tyrosine phosphorylation, thereby establishing binding sites for the small GTPase-activating protein for Ras, p120RasGAP (RasGAP) and the adapter protein Nck. The binding of DOK to the receptor leads to Nck recruitment and subsequent phosphorylation. Binding of Pak to Nck follows. this brings about the Ang-1-dependent phosphorylation of Pak in endothelial cells.

Literature References
Participants
Participant Of
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Orthologous Events