Interaction of Tie2 and Grb2

Stable Identifier
Reaction [binding]
Homo sapiens
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Tie2/Tek provide mitogenic signals to endothelial cells by promoting the association of Grb2 to one of their phosphotyrosines. Grb2 is an adaptor protein that has been linked to activation of Ras and mitogen activated protein kinase (MAPK) cell growth signaling pathways. Grb2 also binds to the Y1102 of the kinase domain of Tie2 with one of its SH2 doamins.

Literature References
PubMed ID Title Journal Year
11191051 Tek/Tie2 signaling: new and old partners

Dumont, DJ, Jones, N

Cancer Metastasis Rev 2000
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

Alitalo, K, Daly, R, Bouchard, D, Jones, J, Master, Z, Sasaki, H, Gunji, Y, Dumont, DJ, Jones, N

J Biol Chem 1999
7478529 GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase

Peters, KG, Turck, CW, Huang, L, Rao, P

Oncogene 1995
Orthologous Events
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