NRIF signals cell death from the nucleus

Stable Identifier
R-HSA-205043
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Pathway
Species
Homo sapiens
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NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor.

Literature References
PubMed ID Title Journal Year
15721744 p75NTR--live or let die

Nykjaer, A, Willnow, TE, Petersen, CM

Curr Opin Neurobiol 2005
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Orthologous Events
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