p75NTR:NADE promotes caspase2/3 activation

Stable Identifier
R-HSA-205117
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Once bound to the NGF:p75NTR complex, NADE contributes to cell death signalling by promoting activation of caspases 2 and 3. It is unclear whether JNK activation is involved. The apoptotic function of NADE was observed in oligodendrocytes (Mukai et al. 2002).
Literature References
PubMed ID Title Journal Year
11830582 Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis

Suvanto, P, Irie, S, Sato, TA, Li, Y, Okubo, S, Mukai, J, Shoji, S, Sano, H, Kimura, MT

J Biol Chem 2002
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activator activity involved in apoptotic process of NGF:p75NTR:NADE [plasma membrane]

Orthologous Events
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