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PIK3R3 [cytosol]
Stable Identifier
R-HSA-205223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3K-p55 gamma, Phosphatidylinositol 3-kinase regulatory subunit gamma, p55PIK
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Phosphorylated KIT mutants bind PI3K (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
GPVI stimulates PI3K beta, gamma (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
PI3K regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
PI3K regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
PI3K regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PIK3C(1) [cytosol] (Homo sapiens)
PIK3CA:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PIK3CB:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3CA:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PIK3CB:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1,RAC2,RHOG activate PI3K (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
G alpha (q) inhibits PI3K alpha (Homo sapiens)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
PI3K binds membrane-associated estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PTK2 is recruited to methylated ESR1 (Homo sapiens)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
PIK3R3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92569 PIK3R3
Gene Names
PIK3R3
Chain
chain:1-461
Reference Genes
BioGPS Gene:8503 PIK3R3
COSMIC (genes):PIK3R3 PIK3R3
CTD Gene:8503 PIK3R3
dbSNP Gene:8503 PIK3R3
ENSEMBL:ENSG00000117461 PIK3R3
HGNC:8981 PIK3R3
KEGG:hsa:8503 PIK3R3
Monarch:8503 PIK3R3
NCBI Gene:8503 PIK3R3
OMIM:606076 PIK3R3
UCSC:Q92569 PIK3R3
Reference Transcript
RefSeq:NM_003629.3 PIK3R3
RefSeq:NM_001114172.1 PIK3R3
RefSeq:NM_001303429.1 PIK3R3
RefSeq:XM_017002614.1 PIK3R3
Other Identifiers
11730844_a_at
11730845_a_at
11730846_x_at
11748828_a_at
11754316_a_at
16686557
202743_PM_at
202743_at
211580_PM_s_at
211580_s_at
2410471
2410472
2410473
2410474
2410475
2410476
2410477
2410479
2410480
2410481
2410482
2410483
2410494
2410495
2410496
2410497
322_at
34479_at
37961_at
7915787
8503
A_33_P3593774
D88532_at
GE57431
GE59549
GE79872
GO:0001784
GO:0001934
GO:0002042
GO:0002376
GO:0003824
GO:0005515
GO:0005829
GO:0005942
GO:0005943
GO:0006629
GO:0006955
GO:0008286
GO:0010628
GO:0016303
GO:0016740
GO:0030154
GO:0030183
GO:0030217
GO:0030335
GO:0036092
GO:0043491
GO:0046854
GO:0046935
GO:0048870
GO:0098772
GO:2000811
HMNXSV003045790
HMNXSV003052145
Hs.88051.0.S2_3p_at
ILMN_1692895
PH_hs_0018015
TC01002616.hg
U90907_at
g3046405_3p_a_at
Participates
as a candidate of
PI3K regulatory subunits [cytosol] (Homo sapiens)
PI3K-regulatory subunits [cytosol] (Homo sapiens)
as a component of
PIK3CA:PIK3R3 [cytosol] (Homo sapiens)
PIK3CD:PIK3R3 [cytosol] (Homo sapiens)
PIK3CB:PIK3R3 [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-PIK3R3 [cytosol]
Inferred To
aap-1 [cytosol]
(Caenorhabditis elegans)
pik3r3a [cytosol]
(Danio rerio)
Pik3r3 [cytosol]
(Mus musculus)
Pik3r3 [cytosol]
(Rattus norvegicus)
PIK3R3 [cytosol]
(Bos taurus)
PIK3R3 [cytosol]
(Gallus gallus)
PIK3R3 [cytosol]
(Sus scrofa)
Pi3K21B [cytosol]
(Drosophila melanogaster)
LOC100856339 [cytosol]
(Canis familiaris)
pik3r3 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003620.3
,
NP_001107644.1
,
XP_016858103.1
,
NP_001290358.1
Guide to Pharmacology - Targets
2505
OpenTargets
ENSG00000117461
ENSEMBL
ENSP00000262741
,
ENSP00000391431
,
ENST00000420542
,
ENST00000423209
,
ENST00000262741
,
ENSP00000361075
,
ENST00000372006
,
ENSP00000412546
HPA
ENSG00000117461-PIK3R3
PRO
Q92569
Pharos - Targets
Q92569
GlyGen
Q92569
HMDB Protein
HMDBP03979
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA [cytosol]
(R-HSA-74787)
PIK3CA R38C [cytosol]
(R-HSA-1500691)
PIK3CA R38G [cytosol]
(R-HSA-2395950)
PIK3CA R38S [cytosol]
(R-HSA-2395947)
PIK3CA R38H [cytosol]
(R-HSA-1500718)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
0.883
47
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.76
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
18
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.666
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.644
5
UniProt:Q05397 PTK2
11
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
PTK2 [cytosol]
(R-HSA-201621)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
0.632
3
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.621
3
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.621
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.59
10
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.57
3
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.57
4
UniProt:P35568 IRS1
5
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
IRS1 [cytosol]
(R-HSA-74769)
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
0.57
4
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.57
4
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [nucleoplasm]
(R-HSA-606325)
ITGB3BP [cytosol]
(R-HSA-3006405)
0.556
3
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.547
2
UniProt:P03496 NS
2
NS1 [nucleoplasm]
(R-FLU-169113)
NS1 [cytosol]
(R-FLU-169118)
0.527
6
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.527
3
UniProt:P43353 ALDH3B1
3
ALDH3B1 [secretory granule membrane]
(R-HSA-6801023)
ALDH3B1 [plasma membrane]
(R-HSA-5696096)
ALDH3B1 [specific granule membrane]
(R-HSA-6799510)
0.527
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:Q9Y4H2 IRS2
4
IRS2 [plasma membrane]
(R-HSA-2428927)
IRS2 [cytosol]
(R-HSA-57528)
p-Y-IRS2 [cytosol]
(R-HSA-74774)
p-Y-IRS2 [plasma membrane]
(R-HSA-198334)
0.527
2
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.488
2
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.488
2
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.488
2
UniProt:Q03112 MECOM
2
MECOM [cytosol]
(R-HSA-5634790)
MECOM [nucleoplasm]
(R-HSA-8943897)
0.488
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.488
2
UniProt:Q06187 BTK
6
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
Active BTK [cytosol]
(R-HSA-8964323)
0.488
2
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.488
2
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