Indirect recruitment of GAB2 to p-KIT

Stable Identifier
R-HSA-205234
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Indirect recruitment of GAB2 to p-KIT
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The scaffolding adapter GAB2 plays a role in KIT dependent PI3K/AKT activation. GAB2 interacts with KIT indirectly via the adapter protein GRB2 which is bound to KIT on phosphorylated Y703 and Y936 (Sun et al. 2008, Yu et al. 2006).

Literature References
PubMed ID Title Journal Year
18697750 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

Sun, J, Pedersen, M, Rönnstrand, L

J Biol Chem 2008
16873377 The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway

Yu, M, Luo, J, Yang, W, Wang, Y, Mizuki, M, Kanakura, Y, Besmer, P, Neel, BG, Gu, H

J Biol Chem 2006
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Indirect recruitment of GAB2 to p-KIT (Bos taurus)
Indirect recruitment of GAB2 to p-KIT (Canis familiaris)
Indirect recruitment of GAB2 to p-KIT (Danio rerio)
Indirect recruitment of GAB2 to p-KIT (Mus musculus)
Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
Indirect recruitment of GAB2 to p-KIT (Sus scrofa)
Indirect recruitment of GAB2 to p-KIT (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2007-12-10)