Interaction of other tyrosine kinases with p-KIT

Stable Identifier
R-HSA-205328
Type
Reaction
Species
Homo sapiens
Compartment
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Cytoplasmic tyrosine kinases such as CHK1 (Csk homologous kinase or MATK), FER and FES associate with p-KIT upon SCF stimulation (Price et al, 19997; Jhun et al, 1995; Craig AW, Greer PA, 2002). TEC has been demonstrated to associate with KIT constitutively and is activated by ligand stimulation (Tang et a l. 1994).

Literature References
PubMed ID Title Journal Year
9038210 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes

Price, DJ, Rivnay, B, Fu, Y, Jiang, S, Avraham, S, Avraham, H

J Biol Chem 1997
12192036 Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells

Craig, AW, Greer, PA

Mol Cell Biol 2002
7536744 The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit

Jhun, BH, Rivnay, B, Price, D, Avraham, H

J Biol Chem 1995
10679268 Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains

Masuhara, M, Nagao, K, Nishikawa, M, Sasaki, M, Yoshimura, A, Osawa, M

Biochem Biophys Res Commun 2000
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

Roskoski, R Jr

Biochem Biophys Res Commun 2005
7526158 Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding

Tang, B, Mano, H, Yi, T, Ihle, JN

Mol Cell Biol 1994
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