Reactome | CSNK1E [cytosol]

CSNK1E [cytosol]

Stable Identifier

R-HSA-205877

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CKIepsilon, Casein kinase I isoform epsilon

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CSNK1E [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49674 CSNK1E

Gene Names

CSNK1E

Chain

chain:1-416

Reference Genes

BioGPS Gene:102800317 CSNK1E

BioGPS Gene:1454 CSNK1E

COSMIC (genes):CSNK1E CSNK1E

CTD Gene:102800317 CSNK1E

CTD Gene:1454 CSNK1E

dbSNP Gene:102800317 CSNK1E

dbSNP Gene:1454 CSNK1E

ENSEMBL:ENSG00000213923 CSNK1E

ENSEMBL:ENSG00000213923.13 CSNK1E

HGNC:2453 CSNK1E

KEGG Gene (Homo sapiens):102800317 CSNK1E

KEGG Gene (Homo sapiens):1454 CSNK1E

Monarch:102800317 CSNK1E

Monarch:1454 CSNK1E

NCBI Gene:102800317 CSNK1E

NCBI Gene:1454 CSNK1E

OMIM:600863 CSNK1E

Reference Transcript

Other Identifiers

11727001_a_at

11727002_a_at

11727003_x_at

11741873_a_at

1454

202332_PM_at

202332_at

225756_PM_at

225756_at

38019_at

3960480

3960481

3960482

3960483

3960484

3960485

3960486

3960490

3960491

3960494

3960495

3960497

3960512

3960514

3960515

3960517

3960518

3960527

3960529

3960530

52939_at

65131_s_at

8076056

90001_s_at

A_23_P29263

A_23_P40664

A_24_P918436

A_33_P3265180

A_33_P3265185

GE53668

GE86394

GO:0000166

GO:0003723

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006468

GO:0006897

GO:0007165

GO:0008104

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0030154

GO:0030163

GO:0030177

GO:0030178

GO:0030426

GO:0032091

GO:0032436

GO:0032880

GO:0032922

GO:0036211

GO:0042752

GO:0043025

GO:0043226

GO:0048511

GO:0048512

GO:0048856

GO:0060070

GO:0090263

GO:0106310

GO:0140096

GO:1902004

GO:1905426

GO:1990090

GO:1990904

GO:2000052

HMNXSV003029637

HMNXSV003057183

Hs.118078.0.A1_3p_at

ILMN_1708858

ILMN_1808913

ILMN_2415235

L37043_at

PH_hs_0028220

TC22001493.hg

g4503092_3p_at

Participates

as a component of

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

as a member of

CSNK1E,CSNK1D [cytosol] (Homo sapiens)

This entity regulates

Positively

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

CSNK1E [nucleoplasm]

Inferred To

Homologues of CSNK1E [cytosol] (Plasmodium falciparum)

Homologues of CSNK1E [cytosol] (Schizosaccharomyces pombe)

CSNK1E [cytosol] (Bos taurus)

CSNK1E [cytosol] (Caenorhabditis elegans)

CSNK1E [cytosol] (Canis familiaris)

CSNK1E [cytosol] (Danio rerio)

CSNK1E [cytosol] (Dictyostelium discoideum)

CSNK1E [cytosol] (Drosophila melanogaster)

CSNK1E [cytosol] (Gallus gallus)

CSNK1E [cytosol] (Mus musculus)

CSNK1E [cytosol] (Plasmodium falciparum)

CSNK1E [cytosol] (Rattus norvegicus)

CSNK1E [cytosol] (Saccharomyces cerevisiae)

CSNK1E [cytosol] (Schizosaccharomyces pombe)

CSNK1E [cytosol] (Sus scrofa)

CSNK1E [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_689407.1, NP_001276841.1, NP_001885.1

ZINC - World Drugs

KC1E_HUMAN

Guide to Pharmacology - Targets

1998

OpenTargets

ENSG00000213923

ZINC - FDA approved

KC1E_HUMAN

ZINC - Substances

KC1E_HUMAN

ZINC - Biogenic

KC1E_HUMAN

ZINC target

P49674

PRO

P49674

PDB

4HOK, 4HNI

ZINC - Investigational

KC1E_HUMAN

GeneCards

P49674

HPA

ENSG00000213923-CSNK1E

Ensembl

ENSG00000213923, ENSP00000380044, ENST00000403904, ENSP00000384074, ENST00000359867, ENSP00000352929, ENST00000396832

Pharos - Targets

P49674

ZINC - Predictions - Purchasable

KC1E_HUMAN

HMDB Protein

HMDBP09459

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15055 PER2	4	Ub-p-S-PER2 [cytosol] (R-HSA-517835) PER2 [cytosol] (R-HSA-400399) p-S-PER2 [nucleoplasm] (R-HSA-3325591) p-S-PER2 [cytosol] (R-HSA-400331)	0.811	6
UniProt:P23508 CRCM			0.809	5
UniProt:Q6ZRV2 FA83H			0.805	9
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.805	9
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.788	5
UniProt:Q16625 OCLN	4	OCLN [cell junction] (R-HSA-2160944) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN [plasma membrane] (R-HSA-351846)	0.787	8
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.745	4
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.738	8
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.687	5
UniProt:Q9BQ89 F110A			0.667	3
UniProt:Q1W6H9 F110C			0.659	3
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.643	5
UniProt:Q8TC76 F110B			0.643	3
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.643	3
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.643	3
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.639	6
UniProt:O70239	5	Axin1 [cytosol] (R-RNO-4641133) phospho-Axin1 [cytosol] (R-RNO-3640864) phospho-Axin1 [cytosol] (R-RNO-3640841) phospho-Axin1 [cytosol] (R-RNO-206040) Axin1 [cytosol] (R-RNO-195249)	0.591	7
UniProt:Q5T7W0 ZN618			0.556	5
UniProt:O75382 TRIM3	1	TRIM3 [cytosol] (R-HSA-5624344)	0.556	3
UniProt:Q9H4H8 FA83D			0.547	2
UniProt:Q60838	5	Dvl2 [cytosol] (R-MMU-4652689) Dvl2 [cytosol] (R-MMU-201694) phospho-Dvl2 [clathrin-coated endocytic vesicle] (R-MMU-5138444) phospho-Dvl2 [cytosol] (R-MMU-201706) phospho-Dvl2 [cytosol] (R-MMU-3772398)	0.544	3
UniProt:Q9P2F5 STOX2			0.527	2
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.527	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	2
UniProt:Q9Y343 SNX24			0.527	2
UniProt:Q8WVL7 ANR49			0.527	2
UniProt:Q9Y343-2 SNX24			0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:A7E2V4 ZSWIM8	1	ZSWIM8 [cytosol] (R-HSA-9011266)	0.527	2
UniProt:Q6PEV8 F199X			0.527	2
UniProt:O94887 FARP2	1	FARP2 [cytosol] (R-HSA-396935)	0.527	2
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012)	0.527	2
UniProt:Q7Z7G8 VP13B			0.527	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.527	2
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.527	2
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.527	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2
UniProt:Q86UY5 FA83A			0.525	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.483	2