Reactome | KPNA2 [cytosol]

KPNA2 [cytosol]

Stable Identifier

R-HSA-205976

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IMA2

Locations in the PathwayBrowser for interactor UniProt:Q53SE7 Q53SE7

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
        
        SARS-CoV-1 6 binds KPNA2 (Homo sapiens)
        
        KPNA2 [cytosol] (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 6 binds KPNA2 (Homo sapiens)
        
        KPNA2 [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)
        
        KPNA2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)
        
        KPNA2 [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)
        
        KPNA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52292 KPNA2

Gene Names

KPNA2, RCH1, SRP1

Chain

initiator methionine:, chain:2-529

Reference Genes

BioGPS Gene:3838 KPNA2

COSMIC (genes):KPNA2 KPNA2

CTD Gene:3838 KPNA2

dbSNP Gene:3838 KPNA2

ENSEMBL:ENSG00000182481 KPNA2

HGNC:6395 KPNA2

KEGG:hsa:3838 KPNA2

Monarch:3838 KPNA2

NCBI Gene:3838 KPNA2

OMIM:600685 KPNA2

UCSC:P52292 KPNA2

Reference Transcript

Other Identifiers

11754765_s_at

16837270

201088_PM_at

201088_at

211762_PM_s_at

211762_s_at

2733255

3060415

3219143

3732624

3732625

3732626

3732627

3732628

3732629

3732630

3732631

3732632

3732633

3732634

3732635

3732636

3732637

3732638

3732639

3732640

3732641

3767054

3838

40407_at

4041118

4041119

4041120

4041121

4041122

4041123

4041124

4041125

4041126

4041127

4041128

4041129

4041130

4041131

4041133

4041134

4041135

4041136

4041137

4041138

4041139

4041140

4041141

8009417

8019737

A_23_P125265

GE61486

GE891781

GO:0000018

GO:0000139

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006259

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0016020

GO:0031965

GO:0032481

GO:0042564

GO:0042826

GO:0043226

GO:0043657

GO:0061608

GO:0075506

GO:0140104

GO:1903902

HMNXSV003033884

ILMN_1661255

ILMN_1665290

ILMN_1678300

ILMN_1701289

ILMN_1721868

ILMN_1746442

PH_hs_0029276

PH_hs_0031923

PH_hs_0040579

TC17002860.hg

U28386_at

g13543656_3p_s_at

g4504896_3p_at

Participates

as a component of

as an input of

as a member of

Importin alpha [cytosol] (Homo sapiens)

Other forms of this molecule

KPNA2 [nucleoplasm]

Inferred To

Homologues of KPNA2 [cytosol] (Plasmodium falciparum)

Kpna2 [cytosol] (Mus musculus)

Kpna2 [cytosol] (Rattus norvegicus)

kpna2 [cytosol] (Danio rerio)

LOC119866208 [cytosol] (Canis familiaris)

KPNA2 [cytosol] (Bos taurus)

KPNA2 [cytosol] (Dictyostelium discoideum)

KPNA2 [cytosol] (Gallus gallus)

KPNA2 [cytosol] (Plasmodium falciparum)

KPNA2 [cytosol] (Sus scrofa)

Pen [cytosol] (Drosophila melanogaster)

ima-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001307540.1, NP_002257.1

OpenTargets

ENSG00000182481

ENSEMBL

ENST00000537025, ENST00000584026, ENSG00000182481, ENST00000579754, ENST00000330459, ENSP00000504655, ENSP00000504685, ENSP00000438483, ENSP00000462331, ENSP00000463602, ENSP00000332455, ENST00000677086, ENST00000679078

GeneCards

KPNA2

HPA

ENSG00000182481-KPNA2

PRO

P52292

Pharos - Targets

P52292

GlyGen

P52292

HMDB Protein

HMDBP08457

PDB

4WV6, 1QGK, 1EFX, 3WPT, 8FZK, 8GCN, 3FEY, 7CRU, 5H43, 3FEX, 4E4V, 7N8J, 7N9H, 1QGR

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.935	14
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.872	14
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.832	13
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.83	9
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.781	8
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.733	7
UniProt:P03101 VL1			0.73	3
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.725	7
UniProt:Q14974-1 KPNB1			0.704	4
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.666	4
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.666	4
UniProt:Q9UJW9 SRTD3			0.666	4
UniProt:O43148 RNMT	1	RNMT [nucleoplasm] (R-HSA-77060)	0.666	4
UniProt:P52298-1 NCBP2			0.659	6
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	6
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.632	4
UniProt:P06703 S10A6			0.611	3
UniProt:P29034 S10A2			0.611	5
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.597	4
UniProt:P03126 VE6			0.592	2
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.589	2
UniProt:P03070 LT			0.571	2
UniProt:K9N643 ORF4B			0.564	2
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.564	2
UniProt:Q9NUW8 TDP1	1	TDP1 [nucleoplasm] (R-HSA-175593)	0.564	2
UniProt:P03107 VL2			0.558	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.556	3
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q9UBU8-2 MORF4L1			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:P63010 AP2B1	4	AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q86Y26 NUTM1			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:Q96C86 DCPS	1	DCPS [cytosol] (R-HSA-429988)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.547	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.547	2
UniProt:Q15020 SART3			0.547	2
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.547	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.527	2
UniProt:Q69YH5 CDCA2			0.527	4
UniProt:Q05D32 CTSL2			0.527	2
UniProt:Q9GZS1 POLR1E	1	POLR1E [nucleoplasm] (R-HSA-5419294)	0.527	2
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.527	2
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	3
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.527	3
UniProt:Q99666 RGPD5			0.527	3
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.527	2
UniProt:Q9H1D9 POLR3F	2	POLR3F [cytosol] (R-HSA-1964434) POLR3F [nucleoplasm] (R-HSA-83708)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q9BW19 KIFC1	1	KIFC1 [cytosol] (R-HSA-990500)	0.527	2
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.527	2
UniProt:Q8WUB8 PHF10	1	PHF10 [nucleoplasm] (R-HSA-9932814)	0.527	2
UniProt:P04620 REV			0.524	2
UniProt:A0A3G5BIZ0 A0A3G5BIZ0			0.524	6
UniProt:P46063 RECQ1			0.508	2
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.508	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.499	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.462	2
UniProt:Q5T7N2 LITD1			0.462	5
UniProt:Q01860 POU5F1 (OCT4)	1	POU5F1 [nucleoplasm] (R-HSA-452472)	0.462	2

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