Phosphorylation of WWTR1 (TAZ) by LATS1

Stable Identifier
R-HSA-2060328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phospho-LATS1, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89. This activity of human LATS1 protein has not been demonstrated experimentally but is inferred from the activity of human paralogue LATS2 and of mouse homologue LATS1 (Varelas et al. 2010).

Literature References
PubMed ID Title Journal Year
20412773 The Hippo pathway regulates Wnt/beta-catenin signaling

Varelas, X, Miller, BW, Sopko, R, Song, S, Gregorieff, A, Fellouse, FA, Sakuma, R, Pawson, T, Hunziker, W, McNeill, H, Wrana, JL, Attisano, L

Dev Cell 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-LATS1:p-MOB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!