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KPNA2 [nucleoplasm]
Stable Identifier
R-HSA-206045
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
IMA2
Locations in the PathwayBrowser for interactor UniProt:P05412 JUN
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Sensing of DNA Double Strand Breaks (Homo sapiens)
KPNA2 translocates NBN to the nucleus (Homo sapiens)
KPNA2 [nucleoplasm] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
KPNA2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
KPNA2 [nucleoplasm] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
KPNA2 [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)
KPNA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52292 KPNA2
Gene Names
KPNA2, RCH1, SRP1
Chain
initiator methionine:1, chain:2-529
Reference Genes
BioGPS Gene:3838 KPNA2
COSMIC (genes):KPNA2 KPNA2
CTD Gene:3838 KPNA2
dbSNP Gene:3838 KPNA2
ENSEMBL:ENSG00000182481 KPNA2
ENSEMBL:ENSG00000182481.10 KPNA2
HGNC:6395 KPNA2
KEGG Gene (Homo sapiens):3838 KPNA2
Monarch:3838 KPNA2
NCBI Gene:3838 KPNA2
OMIM:600685 KPNA2
UCSC:P52292 KPNA2
Reference Transcript
RefSeq:NM_002266.3 KPNA2
RefSeq:NM_001320611.1 KPNA2
Other Identifiers
11754765_s_at
16837270
201088_PM_at
201088_at
211762_PM_s_at
211762_s_at
2733255
3060415
3219143
3732624
3732625
3732626
3732627
3732628
3732629
3732630
3732632
3732633
3732634
3732635
3732637
3732639
3732640
3767054
3838
40407_at
4041120
4041121
4041122
4041124
4041126
4041127
4041130
4041131
4041134
4041135
4041136
4041137
4041138
4041139
4041140
4041141
8009417
8019737
A_23_P125265
GE61486
GO:0000018
GO:0000139
GO:0003723
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006259
GO:0006310
GO:0006606
GO:0006607
GO:0006886
GO:0006913
GO:0008139
GO:0015031
GO:0016020
GO:0031965
GO:0042564
GO:0042826
GO:0043226
GO:0043657
GO:0061608
GO:0075506
GO:0140104
GO:1903902
HMNXSV003033884
ILMN_1678300
ILMN_1701289
ILMN_1746442
PH_hs_0029276
PH_hs_0031923
PH_hs_0040579
TC17002860.hg
U28386_at
g13543656_3p_s_at
g4504896_3p_at
Participates
as an output of
KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
KPNA2 translocates NBN to the nucleus (Homo sapiens)
as a member of
Importin alpha [nucleoplasm] (Homo sapiens)
Other forms of this molecule
KPNA2 [cytosol]
Inferred To
KPNA2 [nucleoplasm]
(Bos taurus)
KPNA2 [nucleoplasm]
(Canis familiaris)
KPNA2 [nucleoplasm]
(Danio rerio)
KPNA2 [nucleoplasm]
(Gallus gallus)
KPNA2 [nucleoplasm]
(Sus scrofa)
kpna2 [nucleoplasm]
(Xenopus tropicalis)
Pen [nucleoplasm]
(Drosophila melanogaster)
Kpna2 [nucleoplasm]
(Mus musculus)
Kpna2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_002257.1
,
NP_001307540.1
OpenTargets
ENSG00000182481
GeneCards
P52292
HPA
ENSG00000182481-KPNA2
Ensembl
ENSP00000332455
,
ENSP00000438483
,
ENST00000537025
,
ENSP00000462331
,
ENSP00000463602
,
ENST00000330459
,
ENST00000579754
,
ENSG00000182481
,
ENST00000584026
,
ENST00000679078
,
ENSP00000504655
,
ENST00000677086
,
ENSP00000504685
PRO
P52292
Pharos - Targets
P52292
Orphanet
29645
HMDB Protein
HMDBP08457
PDB
3FEX
,
8FZK
,
1QGR
,
7N8J
,
7N9H
,
7CRU
,
4WV6
,
5H43
,
3WPT
,
3FEY
,
1EFX
,
1QGK
,
4E4V
Interactors (57)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
0.921
10
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.83
9
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.785
12
UniProt:Q9HAN9 NMNAT1
1
NMNAT1 [nucleoplasm]
(R-HSA-200484)
0.781
8
UniProt:O96017 CHEK2
3
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.733
7
UniProt:P03101 VL1
0.73
3
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.718
9
UniProt:Q14974-1 KPNB1
0.704
4
UniProt:Q9UJW9 SRTD3
0.666
4
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.666
4
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.666
4
UniProt:P52298-1 NCBP2
0.659
6
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.643
6
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.632
4
UniProt:P29034 S10A2
0.611
5
UniProt:P06703 S10A6
0.611
3
UniProt:P03126 VE6
0.592
2
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.589
2
UniProt:P03070 LT
0.571
2
UniProt:K9N643 ORF4B
0.564
2
UniProt:P03107 VL2
0.558
3
UniProt:Q53SE7 Q53SE7
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:P37198 NUP62
2
NUP62 [cytosol]
(R-HSA-9634226)
NUP62 [nuclear envelope]
(R-HSA-157713)
0.556
3
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.556
3
UniProt:Q93062 RBPMS
0.556
3
UniProt:O43148 RNMT
1
RNMT [nucleoplasm]
(R-HSA-77060)
0.556
3
UniProt:Q9UBU8-2 MORF4L1
0.556
3
UniProt:Q7Z6G3-2 NECAB2
0.556
3
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:Q86Y26 NUTM1
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q9NP66 HM20A
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q96C86 DCPS
1
DCPS [cytosol]
(R-HSA-429988)
0.556
3
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.556
3
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.547
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.547
2
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:P04620 REV
0.524
2
UniProt:A0A3G5BIZ0 A0A3G5BIZ0
0.524
6
UniProt:P46063 RECQ1
0.508
2
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.508
4
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.508
3
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.499
3
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.462
3
UniProt:A0A0F6B5H5 A0A0F6B5H5
0.462
2
UniProt:Q01860 POU5F1
1
POU5F1 [nucleoplasm]
(R-HSA-452472)
0.462
2
UniProt:Q5T7N2 LITD1
0.462
5
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