Reactome | GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]

GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]

Stable Identifier

R-HSA-2064082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

syndecan 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P18827 SDC1

Gene Names

SDC1, SDC

Chain

signal peptide:1-22, chain:23-310

Reference Genes

BioGPS Gene:6382 SDC1

COSMIC (genes):SDC1 SDC1

CTD Gene:6382 SDC1

dbSNP Gene:6382 SDC1

ENSEMBL:ENSG00000115884 SDC1

HGNC:10658 SDC1

KEGG:hsa:6382 SDC1

Monarch:6382 SDC1

NCBI Gene:6382 SDC1

OMIM:186355 SDC1

UCSC:P18827 SDC1

Reference Transcript

Other Identifiers

11716577_s_at

11752754_s_at

11758139_s_at

16894911

201286_PM_at

201286_at

201287_PM_s_at

201287_s_at

2542796

2542797

2542798

2542799

2542800

2542801

2542802

2542810

2542811

2542812

2542813

2542814

2542815

38127_at

6382

8050557

A_23_P16944

A_24_P97129

GE60412

GO:0005515

GO:0005576

GO:0005796

GO:0005886

GO:0006898

GO:0009897

GO:0009986

GO:0016020

GO:0016192

GO:0016477

GO:0038024

GO:0042802

GO:0043202

GO:0048627

GO:0048856

GO:0048870

GO:0055002

GO:0060070

GO:0070062

GO:1903543

GO:1903553

HMNXSV003006280

Hs.82109.0.S2_3p_at

ILMN_1768953

ILMN_1800038

ILMN_1815308

PH_hs_0004693

TC02001619.hg

Z48199_at

g4506858_3p_s_at

Participates

as a member of

Other forms of this molecule

HS(4)-SDC1 [plasma membrane]

HS(6)-SDC1 [plasma membrane]

HS(2)-SDC1 [plasma membrane]

HS(1)-SDC1 [plasma membrane]

HS(3)-SDC1 [plasma membrane]

HS(5)-SDC1 [plasma membrane]

SDC1 [plasma membrane]

Gal-Xyl-SDC1 [Golgi lumen]

Gal-Gal-Xyl-SDC1 [Golgi lumen]

XylS-SDC1 [Golgi lumen]

SDC1 [Golgi lumen]

HS(5)-SDC1 [Golgi lumen]

HS(6)-SDC1 [Golgi lumen]

HS(4)-SDC1 [Golgi lumen]

HS(3)-SDC1 [Golgi lumen]

HS(2)-SDC1 [Golgi lumen]

HS(1)-SDC1 [Golgi lumen]

Heparan(4)-SDC1 [Golgi lumen]

Heparan(3)-SDC1 [Golgi lumen]

Heparan(2)-SDC1 [Golgi lumen]

Heparan(1)-SDC1 [Golgi lumen]

Heparan-SDC1 [Golgi lumen]

HS(6)-SDC1 [lysosomal lumen]

GlcA-Gal-Gal-XylP-SDC1 [Golgi lumen]

Inferred To

Sdc1 [Golgi lumen] (Mus musculus)

Sdc1 [Golgi lumen] (Rattus norvegicus)

sdc1 [Golgi lumen] (Xenopus tropicalis)

SDC1 [Golgi lumen] (Bos taurus)

SDC1 [Golgi lumen] (Canis familiaris)

SDC1 [Golgi lumen] (Gallus gallus)

SDC1 [Golgi lumen] (Sus scrofa)

Sdc [Golgi lumen] (Drosophila melanogaster)

sdn-1 [Golgi lumen] (Caenorhabditis elegans)

Modified Residues

Name

O-xylosyl-L-serine (3-O-(β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position

Modification

3-O-(β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

NP_001006947.2, NP_002988.3

OpenTargets

ENSG00000115884

ENSEMBL

ENST00000254351, ENST00000381150, ENSP00000370542, ENSP00000254351, ENSG00000115884

GeneCards

SDC1

HPA

ENSG00000115884-SDC1

PRO

P18827

Pharos - Targets

P18827

GlyGen

P18827

HMDB Protein

HMDBP02143

PDB

4GVC, 6EJE, 4GVD

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01433 AMPD2	1	AMPD2 [cytosol] (R-HSA-49927)	0.669	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.669	4
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) SDC1 [Golgi lumen] (R-HSA-2054105) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314)	0.667	3
UniProt:Q13009 TIAM1	2	TIAM1 [cytosol] (R-HSA-195013) p-Y829-TIAM1 [cytosol] (R-HSA-3928461)	0.655	5
UniProt:Q9UKD1 GMEB2			0.643	3
UniProt:Q8NCB2 CAMKV			0.643	3
UniProt:Q9Y4F1 FARP1	1	FARP1 [cytosol] (R-HSA-9679578)	0.643	3
UniProt:Q13268 DHRS2			0.643	3
UniProt:Q16625 OCLN	4	OCLN [plasma membrane] (R-HSA-351846) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944)	0.643	3
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.643	4
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.59	3
UniProt:Q09666 AHNK			0.564	2
UniProt:Q99985 SEM3C			0.564	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.564	2
UniProt:Q14699 RFTN1			0.564	2
UniProt:Q03468 ERCC6	2	Ub-ERCC6 [nucleoplasm] (R-HSA-6781853) ERCC6 [nucleoplasm] (R-HSA-54429)	0.564	2
UniProt:Q6NZI2 CAVIN1	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.528	2
UniProt:P0DTL6 ZTRF1			0.527	2
UniProt:Q8TAA9 VANGL1	1	VANGL1 [plasma membrane] (R-HSA-9714275)	0.527	2
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.527	2
UniProt:Q9HAV0 GNB4	4	GNB4 [cytosol] (R-HSA-6814417) Partially folded GNB4 [cytosol] (R-HSA-8850525) Unfolded GNB4 [cytosol] (R-HSA-6814201) GNB4 [plasma membrane] (R-HSA-164326)	0.527	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.527	2
UniProt:Q9C0B1 FTO	1	FTO [nucleoplasm] (R-HSA-8857715)	0.527	2
UniProt:Q9Y692 GMEB1			0.527	2
UniProt:Q7L9B9 EEPD1	1	EEPD1 [plasma membrane] (R-HSA-9035163)	0.527	2
UniProt:Q01581 HMGCS1	1	HMGCS1 [cytosol] (R-HSA-191329)	0.527	2
UniProt:P78368 CSNK1G2	2	CSNK1G2 [plasma membrane] (R-HSA-205718) CSNK1G2 [cytosol] (R-HSA-429696)	0.527	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	2
UniProt:P09038 FGF2	1	FGF2(143-288) [extracellular region] (R-HSA-189898)	0.527	2

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