Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
R-HSA-2065357
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Prorenin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
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The binding of prorenin to the (pro)renin receptor activates the protease activity of prorenin, which can then hydrolyze angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Prorenin is inactive when not bound to the (pro)renin receptor. Aliskiren, a drug used clinically to treat hypertension, inhibits the cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References
PubMed ID Title Journal Year
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor

Wood, JM, Maibaum, J, Rahuel, J, Grütter, MG, Cohen, NC, Rasetti, V, Rüger, H, Göschke, R, Stutz, S, Fuhrer, W, Schilling, W, Rigollier, P, Yamaguchi, Y, Cumin, F, Baum, HP, Schnell, CR, Herold, P, Mah, R, Jensen, C, O'Brien, E, Stanton, A, Bedigian, MP

Biochem Biophys Res Commun 2003
22193701 Aliskiren displays long-lasting interactions with human renin

Gossas, T, Vrang, L, Henderson, I, Sedig, S, Sahlberg, C, Lindström, E, Danielson, UH

Naunyn Schmiedebergs Arch Pharmacol 2011
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

Nguyen, G, Delarue, F, Burcklé, C, Bouzhir, L, Giller, T, Sraer, JD

J Clin Invest 2002
Participants
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Event Information
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Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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