Reactome | REN(24-406) [plasma membrane]

REN(24-406) [plasma membrane]

Stable Identifier

R-HSA-2065391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Prorenin, REN, RENI_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P00797 REN

Gene Names

REN

Chain

signal peptide:1-23, propeptide:24-66, chain:67-406

Reference Genes

BioGPS Gene:5972 REN

COSMIC (genes):REN REN

CTD Gene:5972 REN

dbSNP Gene:5972 REN

ENSEMBL:ENSG00000143839 REN

HGNC:9958 REN

KEGG Gene (Homo sapiens):5972 REN

Monarch:5972 REN

NCBI Gene:5972 REN

OMIM:179820 REN

UCSC:P00797 REN

Reference Transcript

RefSeq:NM_000537.3 REN

Other Identifiers

0000730440

11722955_at

16698286

206367_at

2451901

2451902

2451903

2451904

2451905

2451906

2451907

2451909

2451910

2451911

2451912

2451915

2451916

39655_at

5972

7923608

A_23_P34637

GE60508

GO:0000003

GO:0001822

GO:0001823

GO:0002003

GO:0002016

GO:0002018

GO:0003013

GO:0003674

GO:0004175

GO:0004190

GO:0005102

GO:0005159

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005886

GO:0006464

GO:0006508

GO:0006810

GO:0006950

GO:0007165

GO:0007267

GO:0008150

GO:0008217

GO:0008233

GO:0008584

GO:0009755

GO:0010033

GO:0016020

GO:0016787

GO:0021700

GO:0030154

GO:0032496

GO:0034641

GO:0035690

GO:0035902

GO:0042493

GO:0042756

GO:0043408

GO:0045177

GO:0048469

GO:0048856

GO:0050435

GO:0051591

GO:0051604

GO:0070305

ILMN_1742272

M26901_s_at

PH_hs_0000397

TC01003726.hg

TC01006051.hg

g11125774_3p_at

Participant Of

hasComponent

Prorenin-Prorenin Receptor [plasma membrane]

Other forms of this molecule

REN [plasma membrane]

REN [extracellular region]

Inferred To

cathD [plasma membrane] (Drosophila melanogaster)

CG10872 [plasma membrane] (Drosophila melanogaster)

Bace [plasma membrane] (Drosophila melanogaster)

asp-12 [plasma membrane] (Caenorhabditis elegans)

asp-15 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG31928 [plasma membrane] (Drosophila melanogaster)

asp-4 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG6508 [plasma membrane] (Drosophila melanogaster)

asp-9 [plasma membrane] (Caenorhabditis elegans)

asp-1 [plasma membrane] (Caenorhabditis elegans)

asp-18 [plasma membrane] (Caenorhabditis elegans)

REN [plasma membrane] (Canis familiaris)

REN [plasma membrane] (Sus scrofa)

hrg-7 [plasma membrane] (Caenorhabditis elegans)

asp-6 [plasma membrane] (Caenorhabditis elegans)

asp-3 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG10104 [plasma membrane] (Drosophila melanogaster)

ren [plasma membrane] (Danio rerio)

ren [plasma membrane] (Xenopus tropicalis)

Homologues of REN(24-406) [plasma membrane] (Caenorhabditis elegans)

Homologues of REN(24-406) [plasma membrane] (Drosophila melanogaster)

Pgcl [plasma membrane] (Drosophila melanogaster)

Dmel\CG17134 [plasma membrane] (Drosophila melanogaster)

asp-19 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG5863 [plasma membrane] (Drosophila melanogaster)

Dmel\CG5860 [plasma membrane] (Drosophila melanogaster)

asp-13 [plasma membrane] (Caenorhabditis elegans)

asp-16 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG31926 [plasma membrane] (Drosophila melanogaster)

asp-2 [plasma membrane] (Caenorhabditis elegans)

Ren1 [plasma membrane] (Mus musculus)

Ren1 [plasma membrane] (Rattus norvegicus)

asp-17 [plasma membrane] (Caenorhabditis elegans)

asp-5 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000528.1

ZINC - World Drugs

RENI_HUMAN

OpenTargets

ENSG00000143839

ZINC - FDA approved

RENI_HUMAN

ZINC - Substances

RENI_HUMAN

ZINC - Biogenic

RENI_HUMAN

ZINC target

P00797

PRO

P00797

PDB

2G1N, 2G27, 4GJC, 4S1G, 3VYE, 3VCM, 4PYV, 4XX4, 4GJB, 4RYC, 2G26, 5VRP, 1BIL, 2G1S, 1BIM, 3Q4B, 3SFC, 3VYF, 5V8V, 3OAG, 2IKO, 4XX3, 3G6Z, 3VUC, 3Q3T, 5TMK, 2V11, 1BBS, 6I3F, 3G72, 4Q1N, 3O9L, 5SZ9, 2G1O, 4GJ5, 1HRN, 2FS4, 2IKU, 2IL2, 5SXN, 3VSX, 5VPM, 2V13, 2X0B, 1RNE, 2G24, 3OWN, 5SY2, 5T4S, 5TMG, 4RZ1, 4GJ7, 3D91, 3GW5, 4GJD, 2BKT, 2V16, 2G1R, 4RYG, 2BKS, 4GJ6, 3OAD, 5KOT, 2G1Y, 4GJ9, 2V0Z, 2V10, 2G21, 4GJ8, 2G20, 2REN, 3OOT, 5KOQ, 3KM4, 3VYD, 3OQK, 3VSW, 2V12, 3Q5H, 4AMT, 4GJA, 5SY3, 3K1W, 2I4Q, 3G70, 3OQF, 2G22, 5KOS

ZINC - Investigational

RENI_HUMAN

ZINC - Metabolites

RENI_HUMAN

HPA

ENSG00000143839-REN

GeneCards

P00797

Ensembl

ENST00000272190, ENSG00000143839, ENSP00000272190

Orphanet

16807

ZINC - Predictions - Purchasable

RENI_HUMAN

HMDB Protein

HMDBP02624

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01019 AGT	9	AGT(34-41) [extracellular region] (R-HSA-374187) AGT(36-41) [cytosol] (R-HSA-8852193) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT [extracellular region] (R-HSA-1998759) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [cytosol] (R-HSA-8852195)	0.558	2

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