SREBP1A,1C,2 binds the TM7SF2 promoter

Stable Identifier
R-HSA-2065966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Formation of SREBF:NF-Y:TM7SF2 gene complex, Formation of SREBP:NF-Y:TM7SF2 gene complex
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SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).

Literature References
PubMed ID Title Journal Year
18654640 Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

Reed, BD, Charos, AE, Szekely, AM, Weissman, SM, Snyder, M

PLoS Genet 2008
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Rome, S, Lecomte, V, Meugnier, E, Rieusset, J, Debard, C, Euthine, V, Vidal, H, Lefai, E

Physiol Genomics 2008
20138239 Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box

Schiavoni, G, Bennati, AM, Castelli, M, Fazia, MA, Beccari, T, Servillo, G, Roberti, R

Biochim Biophys Acta 2010
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