Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)

Stable Identifier
R-HSA-2066781
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) (this reaction) and the classic 3-ketoacyl-CoA thiolase (Ferdinandusse et al. 2001).

Literature References
PubMed ID Title Journal Year
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ

J Lipid Res 2001
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2 [peroxisomal matrix]
Physical Entity
Activity
Authored
Created
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