Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

Stable Identifier
R-HSA-2066787
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001).

Literature References
PubMed ID Title Journal Year
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
11500517 Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis

Su, HM, Moser, AB, Moser, HW, Watkins, PA

J Biol Chem 2001
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ

J Lipid Res 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acyl-CoA oxidase activity of ACOX1 dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created
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