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Heparan-GPC5 [Golgi lumen]
Stable Identifier
R-HSA-2076472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GlcA-Gal-Gal-Xyl-GPC5, Glypican-5 component recommendedName: Secreted glypican-5 /component, GPC5_HUMAN, GPC5
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-GPC5 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-GPC5 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-GPC5 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-GPC5 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78333 GPC5
Gene Names
GPC5
Chain
signal peptide:1-24, chain:25-, chain:25-, propeptide:-572
Reference Genes
BioGPS Gene:2262 GPC5
COSMIC (genes):GPC5 GPC5
CTD Gene:2262 GPC5
dbSNP Gene:2262 GPC5
ENSEMBL:ENSG00000179399 GPC5
ENSEMBL_homo_sapiens_GENE:ENSG00000179399 GPC5
HGNC:4453 GPC5
KEGG Gene (Homo sapiens):2262 GPC5
Monarch:2262 GPC5
NCBI Gene:2262 GPC5
OMIM:602446 GPC5
UCSC:P78333 GPC5
Reference Transcript
RefSeq:NM_004466.5 GPC5
Other Identifiers
0000050368
11729726_at
11729727_at
16775785
207174_at
2262
3496411
3496412
3496413
3496417
3496445
3496452
3496454
3496469
3496480
3496528
3496529
3496530
3585647
3585660
3613117
3615141
3657682
3658096
36788_at
3688649
3688731
40152
4038869
4039260
44081
7969596
A0A087WX91
A_14_P100211
A_14_P110012
A_23_P112874
A_33_P3368855
AAC12261
AAC51118
AAH39730
AF001462
AK312815
AL138714
AL157363
AL157821
AL162456
AL163537
BAG35673
BC039730
CCDS9468
ENSG00000179399
ENSP00000366267
ENST00000377067
EntrezGene:2262
g5360214_3p_at
GE58336
GO:0001523
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0006024
GO:0006027
GO:0006629
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0009966
GO:0016020
GO:0016021
GO:0031012
GO:0031225
GO:0043202
GO:0043226
GO:0046658
GO:0062023
GPC5
GPC5-201
HGNC:4453
HPA040152
HPA044081
ILMN_1688886
IPR001863
IPR019803
IPR031188
MIM:602446
NM_004466
NP_004457
PF01153
PH_hs_0026289
PH_hs_0028978
TC13000323.hg
U66033
U66033_at
uc010tif.4
UPI0000001C85
XM_011521054
XM_017020435
XM_017020437
XP_011519356
XP_016875924
XP_016875926
Participant Of
hasMember
Heparan-PGs [Golgi lumen]
Other forms of this molecule
GPI-cleaved GPC5 [extracellular region]
GPI-GPC5 [plasma membrane]
GPC5(25-?) [plasma membrane]
Heparan(1)-GPC5 [Golgi lumen]
Heparan(2)-GPC5 [Golgi lumen]
Heparan(3)-GPC5 [Golgi lumen]
Heparan(4)-GPC5 [Golgi lumen]
Gal-Gal-Xyl-GPC5 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC5 [Golgi lumen]
Gal-Xyl-GPC5 [Golgi lumen]
XylS-GPC5(25-?) [Golgi lumen]
GPC5(25-?) [Golgi lumen]
HS(6)-GPC5 [lysosomal lumen]
GPC5(25-?) [lysosomal lumen]
HS(6)-GPC5 [plasma membrane]
HS(5)-GPC5 [Golgi lumen]
HS(4)-GPC5 [Golgi lumen]
HS(2)-GPC5 [Golgi lumen]
HS(3)-GPC5 [Golgi lumen]
HS(6)-GPC5 [Golgi lumen]
HS(1)-GPC5 [Golgi lumen]
HS(4)-GPC5 [plasma membrane]
HS(2)-GPC5 [plasma membrane]
HS(1)-GPC5 [plasma membrane]
HS(3)-GPC5 [plasma membrane]
HS(5)-GPC5 [plasma membrane]
Inferred To
Homologues of Heparan-GPC5 [Golgi lumen] (Canis familiaris)
Homologues of Heparan-GPC5 [Golgi lumen] (Gallus gallus)
Homologues of Heparan-GPC5 [Golgi lumen] (Sus scrofa)
Heparan-GPC5 [Golgi lumen] (Bos taurus)
Heparan-GPC5 [Golgi lumen] (Canis familiaris)
Heparan-GPC5 [Golgi lumen] (Danio rerio)
Heparan-GPC5 [Golgi lumen] (Gallus gallus)
Heparan-GPC5 [Golgi lumen] (Mus musculus)
Heparan-GPC5 [Golgi lumen] (Sus scrofa)
Heparan-GPC5 [Golgi lumen] (Taeniopygia guttata)
Heparan-GPC3 [Golgi lumen] (Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63645) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_004457.1
OpenTargets
ENSG00000179399
GeneCards
P78333
PRO
P78333
Orphanet
24569
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