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Heparan-AGRN [Golgi lumen]
Stable Identifier
R-HSA-2076530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GlcA-Gal-Gal-Xyl-AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
BioGPS Gene:375790 AGRN
COSMIC (genes):AGRN AGRN
CTD Gene:375790 AGRN
dbSNP Gene:375790 AGRN
ENSEMBL:ENSG00000188157 AGRN
ENSEMBL_homo_sapiens_GENE:ENSG00000188157 AGRN
HGNC:329 AGRN
KEGG Gene (Homo sapiens):375790 AGRN
Monarch:375790 AGRN
NCBI Gene:375790 AGRN
OMIM:103320 AGRN
UCSC:O00468 AGRN
Reference Transcript
RefSeq:NM_198576.3 AGRN
RefSeq:NM_001305275.1 AGRN
RefSeq:XM_005244749.3 AGRN
Other Identifiers
0002680427
11732450_s_at
11732451_a_at
16657598
212283_at
212285_s_at
217419_x_at
33454_at
375790
40090
4053551
4053554
4053565
4053573
4053574
4053575
4053576
4053579
4053580
4053581
4053582
4053583
4053584
4053586
4053588
4053589
4053590
4053591
4053592
4053594
4053595
4053598
4053600
4053602
4053604
4053605
4053606
4053608
4053609
4053610
4053611
4053612
4053613
4053614
4053615
4053616
4053617
4053618
4053619
4053627
4053629
4053631
4053632
4053633
4053634
4053635
4053636
4053637
4053638
7896822
A0A087X208
A0A1W2PRQ9
A_23_P343411
A_24_P24819
A_24_P358462
AGRN
AGRN-201
CCDS30551
ENSG00000188157
ENSP00000368678
ENST00000379370
EntrezGene:375790
GO:0001523
GO:0002162
GO:0003674
GO:0005198
GO:0005200
GO:0005201
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005604
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0006024
GO:0006027
GO:0006629
GO:0007010
GO:0007165
GO:0007213
GO:0007275
GO:0008150
GO:0008582
GO:0009056
GO:0009058
GO:0016020
GO:0016021
GO:0021700
GO:0022607
GO:0030054
GO:0030154
GO:0030198
GO:0031012
GO:0033691
GO:0034641
GO:0035374
GO:0040007
GO:0043113
GO:0043167
GO:0043202
GO:0043226
GO:0043236
GO:0043395
GO:0043547
GO:0045162
GO:0045202
GO:0045887
GO:0045944
GO:0048856
GO:0050808
GO:0051491
GO:0061024
GO:0062023
GO:0070062
HGNC:329
Hs.273330.1.S1_3p_at
Hs.273330.2.S1_3p_a_at
ILMN_1770454
ILMN_2234605
IPR000082
IPR000742
IPR001791
IPR001881
IPR002049
IPR002350
IPR003645
IPR003884
IPR004850
IPR008993
IPR013032
IPR013320
IPR036058
IPR036364
LRG_198
MIM:103320
MIM:615120
NM_001364727
NM_198576
NP_001351656
NP_940978
PF00008
PF00050
PF00053
PF00054
PF01390
PF03146
PF07648
PH_hs_0032416
PR00011
SM00057
SM00179
SM00180
SM00181
SM00200
SM00274
SM00280
SM00282
TC01000024.hg
uc001ack.3
UPI00001D7C8B
XM_005244749
XM_011541429
XP_005244806
XP_011539731
XR_946650
Participant Of
hasMember
Heparan-PGs [Golgi lumen]
Other forms of this molecule
AGRN(30-2045) [plasma membrane]
Heparan(1)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
HS(5)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(4)-AGRN [plasma membrane]
HS(1)-AGRN [Golgi lumen]
AGRN(30-2045) [extracellular region]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
XylS-AGRN(30-2045) [Golgi lumen]
AGRN(30-2045) [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
HS(6)-AGRN [plasma membrane]
HS(5)-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
Inferred To
Heparan-AGRN [Golgi lumen] (Bos taurus)
Heparan-AGRN [Golgi lumen] (Caenorhabditis elegans)
Heparan-AGRN [Golgi lumen] (Canis familiaris)
Heparan-AGRN [Golgi lumen] (Danio rerio)
Heparan-AGRN [Golgi lumen] (Gallus gallus)
Heparan-AGRN [Golgi lumen] (Mus musculus)
Heparan-AGRN [Golgi lumen] (Rattus norvegicus)
Heparan-AGRN [Golgi lumen] (Sus scrofa)
Heparan-AGRN [Golgi lumen] (Taeniopygia guttata)
Heparan-AGRN [Golgi lumen] (Xenopus tropicalis)
Homologues of Heparan-AGRN [Golgi lumen] (Danio rerio)
Homologues of Heparan-AGRN [Golgi lumen] (Gallus gallus)
Homologues of Heparan-AGRN [Golgi lumen] (Rattus norvegicus)
Homologues of Heparan-AGRN [Golgi lumen] (Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63645) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_940978.2
,
NP_001292204.1
,
XP_005244806.1
OpenTargets
ENSG00000188157
GeneCards
O00468
PRO
O00468
Orphanet
19233
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15265 ATXN7
2
ATXN7 [cytosol]
(R-HSA-201591)
ATXN7 [nucleoplasm]
(R-HSA-8869458)
0.508
2
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