Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
HS(6)-SDC2 [lysosomal lumen]
Stable Identifier
R-HSA-2090064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
SDC2, HSPG, SDC2_HUMAN, Heparan sulfate proteoglycan core protein
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
HS/HPIN-PGs [lysosomal lumen] (Homo sapiens)
HS(6)-SDC2 [lysosomal lumen] (Homo sapiens)
Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)
HS/HPIN-PGs [lysosomal lumen] (Homo sapiens)
HS(6)-SDC2 [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34741 SDC2
Gene Names
SDC2, HSPG1
Chain
signal peptide:1-18, chain:19-201
Reference Genes
BioGPS Gene:6383 SDC2
COSMIC (genes):SDC2 SDC2
CTD Gene:6383 SDC2
dbSNP Gene:6383 SDC2
ENSEMBL:ENSG00000169439 SDC2
HGNC:10659 SDC2
KEGG Gene (Homo sapiens):6383 SDC2
Monarch:6383 SDC2
NCBI Gene:6383 SDC2
OMIM:142460 SDC2
UCSC:P34741 SDC2
Reference Transcript
RefSeq:NM_002998.3 SDC2
Other Identifiers
11720753_s_at
11745006_a_at
11745007_s_at
11746797_a_at
11746798_x_at
11751122_x_at
17071144
212154_at
212157_at
212158_at
3108152
3108153
3108154
3108155
3108156
3108157
3108158
3108184
3108185
3108186
3108187
3108188
3108189
3108190
3108191
3108192
3108210
3108212
39757_at
6383
65000_at
8147461
A_14_P109550
A_24_P380734
A_33_P3371219
GE57514
GO:0000902
GO:0001523
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006024
GO:0006027
GO:0006464
GO:0006629
GO:0007165
GO:0007399
GO:0008150
GO:0009056
GO:0009058
GO:0009986
GO:0016020
GO:0016021
GO:0016477
GO:0030154
GO:0030165
GO:0031012
GO:0040011
GO:0042802
GO:0043202
GO:0043226
GO:0043687
GO:0044267
GO:0048013
GO:0048813
GO:0048814
GO:0048856
GO:0048870
GO:0050900
GO:0062023
Hs.1501.0.S1_3p_at
Hs.1501.0.S2_3p_at
Hs.1501.0.S3_3p_at
ILMN_1784553
J04621_at
PH_hs_0000201
TC08000590.hg
Participant Of
hasMember
HS/HPIN-PGs [lysosomal lumen]
Other forms of this molecule
p-Y179,Y191-SDC2 [plasma membrane]
p-SDC2 [endoplasmic reticulum lumen]
SDC2 [endoplasmic reticulum lumen]
SDC2 [plasma membrane]
SDC2 [lysosomal lumen]
HS(5)-SDC2 [plasma membrane]
HS(3)-SDC2 [plasma membrane]
HS(1)-SDC2 [plasma membrane]
HS(2)-SDC2 [plasma membrane]
HS(6)-SDC2 [plasma membrane]
HS(4)-SDC2 [plasma membrane]
HS(6)-SDC2 [Golgi lumen]
HS(5)-SDC2 [Golgi lumen]
Heparan-SDC2 [Golgi lumen]
XylS-SDC2 [Golgi lumen]
Gal-Xyl-SDC2 [Golgi lumen]
SDC2 [Golgi lumen]
Gal-Gal-Xyl-SDC2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
HS(3)-SDC2 [Golgi lumen]
HS(4)-SDC2 [Golgi lumen]
HS(2)-SDC2 [Golgi lumen]
HS(1)-SDC2 [Golgi lumen]
Heparan(4)-SDC2 [Golgi lumen]
Heparan(3)-SDC2 [Golgi lumen]
Heparan(2)-SDC2 [Golgi lumen]
Heparan(1)-SDC2 [Golgi lumen]
Inferred To
sdn-1 [lysosomal lumen] (Caenorhabditis elegans)
SDC2 [lysosomal lumen] (Canis familiaris)
SDC2 [lysosomal lumen] (Gallus gallus)
SDC2 [lysosomal lumen] (Sus scrofa)
sdc2 [lysosomal lumen] (Danio rerio)
Sdc [lysosomal lumen] (Drosophila melanogaster)
Sdc2 [lysosomal lumen] (Mus musculus)
Sdc2 [lysosomal lumen] (Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002989.2
OpenTargets
ENSG00000169439
HPA
ENSG00000169439-SDC2
GeneCards
P34741
Ensembl
ENSG00000169439
,
ENST00000302190
,
ENSP00000307046
PRO
P34741
HMDB Protein
HMDBP10737
PDB
6ITH
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34741 SDC2
28
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
SDC2 [plasma membrane]
(R-HSA-2090052)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
SDC2 [Golgi lumen]
(R-HSA-2054101)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
0.655
4
UniProt:P41271-2 NBL1
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [cytosol]
(R-HSA-5654207)
SPRED1 [plasma membrane]
(R-HSA-5658225)
0.556
3
UniProt:Q13387-4 MAPK8IP2
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802312)
p-ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:P28799 GRN
2
GRN [extracellular region]
(R-HSA-6806217)
GRN [azurophil granule lumen]
(R-HSA-6799168)
0.556
3
UniProt:O60784-2 TOM1
0.556
3
IntAct:EBI-25834291 CCSB
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q12797-6 ASPH
0.556
5
UniProt:P28799-2 GRN
0.556
3
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.556
3
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.527
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text