PPM1A dephosphorylates nuclear SMAD2/3

Stable Identifier
R-HSA-209055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.

Literature References
PubMed ID Title Journal Year
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Lin, X, Duan, X, Liang, YY, Su, Y, Wrighton, KH, Long, J, Hu, M, Davis, CM, Wang, J, Brunicardi, FC, Shi, Y, Chen, YG, Meng, A, Feng, XH

Cell 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created