PPM1A dephosphorylates nuclear SMAD2/3

Stable Identifier
R-HSA-209055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.
Literature References
PubMed ID Title Journal Year
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Wrighton, KH, Shi, Y, Liang, YY, Brunicardi, FC, Duan, X, Feng, XH, Chen, YG, Su, Y, Lin, X, Hu, M, Meng, A, Wang, J, Davis, CM, Long, J

Cell 2006
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm]

Orthologous Events
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