Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex

Stable Identifier
Reaction [omitted]
Homo sapiens
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Ubiquitinated IKBA is degraded by the proteasome complex.
Literature References
PubMed ID Title Journal Year
10514433 Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

Matsumoto, M, Hatakeyama, S, Shirane, M, Hattori, K, Nakayama, K

J Biol Chem 1999
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Scherer, D, Chen, Z, Hagler, J, Palombella, VJ, Ballard, D, Maniatis, T, Melandri, F

Genes Dev 1995
9990853 Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Jiang, J, Spencer, E, Chen, ZJ

Genes Dev 1999
10075690 Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP

Margottin, F, Bachelerie, F, Kohl, A, Benarous, R, Concordet, JP, Durand, H, Arenzana-Seisdedos, F, Renard, P, Kroll, M

J Biol Chem 1999
10918611 SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

Boisclair, M, Auger, KR, Beer-Romero, P, Parsons, T, Theodoras, A, Strack, P, Rolfe, M, Benfield, P, Copeland, RA, Pelletier, M, Caligiuri, M, Glass, S, Brizuela, L

Oncogene 2000
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y

Nature 1998
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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