Methylation of N-acetyl-5-HT to form melatonin

Stable Identifier
R-HSA-209821
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of melatonin. Melatonin is synthesized and released by the pineal gland and is thought to control circadian rhythms. HIOMT has 3 isoforms and utilizes S-adenosyl-L-methionine (SAM) as the methyl donor in the conversion of N-acetyl-5HT to melatonin.

Literature References
PubMed ID Title Journal Year
7989373 Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.

Rodriguez, IR, Mazuruk, K, Schoen, TJ, Chader, GJ

J Biol Chem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
S-methyltransferase activity of ASMT [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created